Evidence map›Paper›PMID 29540998›Full record

ReviewClinical and molecular allergy : CMA2018

Bench to bedside review of myositis autoantibodies.

Boaz Palterer, Gianfranco Vitiello, Alessia Carraresi, Maria Grazia Giudizi, Daniele Cammelli, Paola Parronchi

Abstract readReview
In one paragraph

Review in Clinical and molecular allergy : CMA, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Trial
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  5. Review
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  9. Observational
  10. Neoself Antigens Presented on MHC Class II Molecules in Autoimmune Diseases.Advances in experimental medicine and biology · 2024
    Article
  11. Research progress on the dermatomyositis specific autoantibodies and malignancy associated dermatomyositis.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Boaz PaltererExperimental and Clinical Medicine Department, University of Florence, Largo Brambilla 3, 50134 Florence, Italy.ORCID 0000-0003-2499-8250
Gianfranco VitielloExperimental and Clinical Medicine Department, University of Florence, Largo Brambilla 3, 50134 Florence, Italy.
Alessia CarraresiExperimental and Clinical Medicine Department, University of Florence, Largo Brambilla 3, 50134 Florence, Italy.
Maria Grazia GiudiziExperimental and Clinical Medicine Department, University of Florence, Largo Brambilla 3, 50134 Florence, Italy.
Daniele CammelliExperimental and Clinical Medicine Department, University of Florence, Largo Brambilla 3, 50134 Florence, Italy.
Paola ParronchiExperimental and Clinical Medicine Department, University of Florence, Largo Brambilla 3, 50134 Florence, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Idiopathic inflammatory myopathies represent a heterogeneous group of autoimmune diseases with systemic involvement. Even though numerous specific autoantibodies have been recognized, they have not been included, with the only exception of anti-Jo-1, into the 2017 Classification Criteria, thus perpetuating a clinical-serologic gap. The lack of homogeneous grouping based on the antibody profile deeply impacts the diagnostic approach, therapeutic choices and prognostic stratification of these patients. This review is intended to highlight the comprehensive scenario regarding myositis-related autoantibodies, from the molecular characterization and biological significance to target antigens, from the detection tools, with a special focus on immunofluorescence patterns on HEp-2 cells, to their relative prevalence and ethnic diversity, from the clinical presentation to prognosis. If, on the one hand, a notable body of literature is present, on the other data are fragmented, retrospectively based and collected from small case series, so that they do not sufficiently support the decision-making process (i.e. therapeutic approach) into the clinics.

Indexed as

Anti-nuclear antibodiesAutoantibodiesDermatomyositisHMGCRImmune-mediated necrotizing myopathyImmunofluorescenceInclusion body myositisMDA5MyositisPolymyositis

Identifiers

PMID29540998
PMCPMC5840827

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.