ArticleScientific reports2018
Origami-based self-folding of co-cultured NIH/3T3 and HepG2 cells into 3D microstructures.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 38 citations in OpenAlex.
- Transcription factor 19 modulates fatty acid elongation and unfolded protein response to attenuate palmitic acid-induced hepatic dysfunction.Nature communications · 2026Article
- Transformative bioprinting: 4D printing and its role in the evolution of engineering and personalized medicine.Discover nano · 2025Review
- Bilayer 3D co-culture platform inducing the differentiation of normal fibroblasts into cancer-associated fibroblast like cells: New in vitro source to obtain cancer-associated fibroblasts.Bioengineering & translational medicine · 2025Article
- Conditioned serum-free culture medium accomplishes adhesion and proliferation of bovine myogenic cells on uncoated dishes.NPJ science of food · 2024Article
- The Promise and Challenges of Bioprinting in Tissue Engineering.Micromachines · 2024Article
- Indirect 3D Bioprinting of a Robust Trilobular Hepatic Construct with Decellularized Liver Matrix Hydrogel.Bioengineering (Basel, Switzerland) · 2022Article
- 3D bioprinting of hepatocytes: core-shell structured co-cultures with fibroblasts for enhanced functionality.Scientific reports · 2021Article
- Origami-Inspired Approaches for Biomedical Applications.ACS omega · 2021Review
- Session 1SCA-Utilizing soft compartments/interfaces for the creation of artificial biosystems.Biophysical reviews · 2020Article
- Perspective of Molecular Diagnosis in Healthcare: From Barcode to Pattern Recognition.Diagnostics (Basel, Switzerland) · 2019Article
- Modelling Cell Origami via a Tensegrity Model of the Cytoskeleton in Adherent Cells.Applied bionics and biomechanics · 2019Article
- Origami Biosystems: 3D Assembly Methods for Biomedical Applications.Advanced biosystems · 2018Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper describes an origami-inspired self-folding method to form three-dimensional (3D) microstructures of co-cultured cells. After a confluent monolayer of fibroblasts (NIH/3T3 cells) with loaded hepatocytes (HepG2 cells) was cultured onto two-dimensional (2D) microplates, degradation of the alginate sacrificial layer in the system by addition of alginate lyase triggered NIH/3T3 cells to self-fold the microplates around HepG2 cells, and then 3D cell co-culture microstructures were spontaneously formed. Using this method, we can create a large number of 3D cell co-culture microstructures swiftly with ease in the same time. We find that HepG2 cells confined in the 3D cell co-culture microstructures have an ability to enhance the secreted albumin compared to 2D system in a long culture period. The result indicates that the origami-based cell self-folding technique presented here is useful in regenerative medicine and the preclinical stage of drug development.
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