Evidence map›Paper›PMID 29540727›Full record

ArticleScientific reports2018

High-mobility group box 1 facilitates migration of neural stem cells via receptor for advanced glycation end products signaling pathway.

Xin Xue, Xingxing Chen, Weili Fan, Guan Wang, Liang Zhang, Zongfeng Chen, Peng Liu, Mingyong Liu, Jianhua Zhao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Xin XueDepartment of Spinal Surgery, Daping Hospital, Research Institute of Surgery, The Third Military Medical University, Chongqing, China.
Xingxing ChenDepartment of Spinal Surgery, Daping Hospital, Research Institute of Surgery, The Third Military Medical University, Chongqing, China.
Weili FanDepartment of Spinal Surgery, Daping Hospital, Research Institute of Surgery, The Third Military Medical University, Chongqing, China.
Guan WangDepartment of Spinal Surgery, Daping Hospital, Research Institute of Surgery, The Third Military Medical University, Chongqing, China.
Liang ZhangDepartment of Spinal Surgery, Daping Hospital, Research Institute of Surgery, The Third Military Medical University, Chongqing, China.
Zongfeng ChenDepartment of Spinal Surgery, Daping Hospital, Research Institute of Surgery, The Third Military Medical University, Chongqing, China.
Peng LiuDepartment of Spinal Surgery, Daping Hospital, Research Institute of Surgery, The Third Military Medical University, Chongqing, China.
Mingyong LiuDepartment of Spinal Surgery, Daping Hospital, Research Institute of Surgery, The Third Military Medical University, Chongqing, China. mingyong_liu@163.com.
Jianhua ZhaoDepartment of Spinal Surgery, Daping Hospital, Research Institute of Surgery, The Third Military Medical University, Chongqing, China. zhaojianhua1964@yahoo.com.
Army Medical University · CNDaping Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High-mobility group box 1 (HMGB1) facilitates neural stem cells (NSCs) proliferation and differentiation into neuronal linage. However, the effect of HMGB1 on NSCs migration is still elusive. The present study is to investigate the corelation between HMGB1 and NSCs migration and the potential mechanism. The results indicated that 1 ng/ml HMGB1 promoted NSCs proliferation using CCK8 assays. Moreover, data showed that 1 ng/ml HMGB1 facilitated NSCs migration via filopodia formation using phase-contrast and transwell assays. Furthermore, 1 ng/ml HMGB1 upregulated the expression of RAGE, one of the HMGB1 receptor, using western blotting assays and immunofluorescence staining. In addition, 1 ng/ml HMGB1 increased the percentage of filopodia formation using phalloidin staining. Meanwhile, the enhanced migration effect could be abrogated by 50 nM FPS-ZM1, one of the RAGE antagonist, and RAGE-specific siRNA through immunofluorescence and phalloidin staining. Together, our data demonstrate that HMGB1/RAGE axis facilitates NSCs migration via promoting filopodia formation, which might serve as a candidate for central nervous system (CNS) injury treatment and/or a preconditioning method for NSCs implantation.

Indexed as

Signal TransductionAnimalsCell DifferentiationCell MovementCell ProliferationGene Expression RegulationGlycation End Products, AdvancedHMGB1 ProteinMiceNeural Stem CellsPseudopodiaReceptor for Advanced Glycation End ProductsGlycation End Products, AdvancedHMGB1 ProteinReceptor for Advanced Glycation End Products

Identifiers

PMID29540727
PMCPMC5852130
OpenAlexW2807262818

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.