ArticleNature communications2018
Predicting the spatiotemporal diversity of seizure propagation and termination in human focal epilepsy.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.
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Who cites it
77 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pharmacological intervention for irritability, aggression, and self-injury in autism spectrum disorder (ASD).The Cochrane database of systematic reviews · 2023Pooled it
- Influences of electrode density on intracranial seizure localisation: a single-blinded randomised crossover study.EBioMedicine · 2025Trial
- Robust time delay estimation for measurement of ictal EEG traveling waves.Journal of neural engineering · 2026Article
- Seizure recruitment properties are dependent upon dynamotype: A modeling study.PLoS computational biology · 2026Article
- The Free Energy Principle and Free Markets.Entropy (Basel, Switzerland) · 2026Article
- Mapping the Phenotypic Spectrum of Occipital Lobe Epilepsy: A SEEG-Defined Network Classification.CNS neuroscience & therapeutics · 2026Article
- Structural Eigenmodes of the Brain to Improve the Source Localization of EEG: Application to Epileptiform Activity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Anti-Seizure Medications Alter Functional and Effective Connectivity as Measured With Intracranial Electroencephalography.Brain and behavior · 2026Article
- Co-simulation framework combining a microscopically detailed point neuron model of the hippocampal CA1 region with the macroscopic high-resolution virtual brain model.Journal of computational neuroscience · 2026Article
- Knowledge graph representation of the mappings between seizure semiology and epileptogenic zones.Scientific reports · 2026Article
- High-resolution Bayesian Virtual Epileptic Patient using neural field models.Network neuroscience (Cambridge, Mass.) · 2026Article
- [Localizing target for transcranial electrical stimulation in epilepsy patients combining scalp electroencephalogram and neural computational model].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025Article
- Modelling dysfunction-specific interventions for seizure termination in epilepsy.NPJ systems biology and applications · 2025Article
- Article
- Review
- Interictal discharges spread along local recurrent networks between tubers and surrounding cortex.The Journal of physiology · 2025Article
- Virtual epilepsy patient cohort: Generation and evaluation.PLoS computational biology · 2025Article
- Downmodulation of Potassium Conductances Induces Epileptic Seizures in Cortical Network Models Via Multiple Synergistic Factors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Controllability of nonlinear epileptic-seizure spreading dynamics in large-scale subject-specific brain networks.Scientific reports · 2025Article
17 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
Abstract
Recent studies have shown that seizures can spread and terminate across brain areas via a rich diversity of spatiotemporal patterns. In particular, while the location of the seizure onset area is usually invariant across seizures in an individual patient, the source of traveling (2-3 Hz) spike-and-wave discharges during seizures can either move with the slower propagating ictal wavefront or remain stationary at the seizure onset area. Furthermore, although many focal seizures terminate synchronously across brain areas, some evolve into distinct ictal clusters and terminate asynchronously. Here, we introduce a unifying perspective based on a new neural field model of epileptic seizure dynamics. Two main mechanisms, the co-existence of wave propagation in excitable media and coupled-oscillator dynamics, together with the interaction of multiple time scales, account for the reported diversity. We confirm our predictions in seizures and tractography data obtained from patients with pharmacologically resistant epilepsy. Our results contribute toward patient-specific seizure modeling.
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