Evidence map›Paper›PMID 29540664›Full record

ArticleTranslational psychiatry2018

Prebiotic attenuation of olanzapine-induced weight gain in rats: analysis of central and peripheral biomarkers and gut microbiota.

Amy Chia-Ching Kao, Sonia Spitzer, Daniel C Anthony, Belinda Lennox, Philip W J Burnet

Open access · goldAbstract read
In one paragraph

Article in Translational psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 4 pooled it
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 4 syntheses or guidelines pooled it, 126 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Colon-delivered short-chain fatty acids attenuate the cortisol response to psychosocial stress in healthy men: a randomized, placebo-controlled trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020
    Trial
  7. Trial
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Frontiers in pharmacology · 2025
    Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Amy Chia-Ching KaoDepartment of Psychiatry, University of Oxford, Oxford, OX3 7JX, UK.
Sonia SpitzerDepartment of Psychiatry, University of Oxford, Oxford, OX3 7JX, UK.
Daniel C AnthonyDepartment of Pharmacology, University of Oxford, Oxford, OX1 3QT, UK.
Belinda LennoxDepartment of Psychiatry, University of Oxford, Oxford, OX3 7JX, UK.ORCID http://orcid.org/0000-0002-4972-8786
Philip W J BurnetDepartment of Psychiatry, University of Oxford, Oxford, OX3 7JX, UK. phil.burnet@psych.ox.ac.uk.
University of Oxford · GB

Funding

Biotechnology and Biological Sciences Research Council BB/N010035/1
6 · The paper itself

Abstract

Olanzapine is an effective antipsychotic drug but since it causes significant weight gain, it is not well tolerated by psychosis patients. The prebiotic, B-GOS

Indexed as

Gastrointestinal MicrobiomeAnimalsAntipsychotic AgentsBiomarkersCerebral CortexFecesFemaleOlanzapinePrebioticsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateReceptors, SerotoninWeight GainAntipsychotic AgentsBiomarkersOlanzapinePrebioticsReceptors, N-Methyl-D-AspartateReceptors, Serotonin

Identifiers

PMID29540664
PMCPMC5852210
OpenAlexW2792991637

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.