ArticleInternal medicine (Tokyo, Japan)2018
Possible Combined Central and Peripheral Demyelination Presenting as Optic Neuritis, Cervical Myelitis, and Demyelinating Polyneuropathy with Marked Nerve Hypertrophy.
Article in Internal medicine (Tokyo, Japan), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 5 citations in OpenAlex.
- Case Report of Combined Central and Peripheral Demyelination: Treated With Ofatumumab.Immunity, inflammation and disease · 2026Article
- Combined Central and Peripheral Demyelination with a Favorable Outcome: A Case with 10-Year Follow-up.Noro psikiyatri arsivi · 2026Article
- Immune-mediated insights into clinical and specific autoantibodies in acute and chronic immune-mediated nodo-paranodopathies.Arquivos de neuro-psiquiatria · 2025Review
- Is MS affecting the CNS only? Lessons from clinic to myelin pathophysiology.Neurology(R) neuroimmunology & neuroinflammation · 2021Review
- Concurrent leukoencephalomyelitis and polyneuritis in a Maltese terrier: resembling combined central and peripheral demyelination in humans.The Journal of veterinary medical science · 2019Article
- MOG antibodies in combined central and peripheral demyelination syndromes.Neurology(R) neuroimmunology & neuroinflammation · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A 27-year-old woman with optic neuritis and cervical myelitis developed hypertrophic demyelinating polyneuropathy. It was hypothesized that the diagnosis was combined central and peripheral demyelination. A hypertrophic nerve was observed subcutaneously, and magnetic resonance imaging demonstrated marked hypertrophy of the nerve roots. The patient was negative for anti-aquaporin 4 antibodies. Her anti-neurofascin 155 antibody levels was slightly elevated, but it was not definitely positive. Pulsed steroid therapy and the administration of immunoglobulin ameliorated her symptoms. Molecules in both the peripheral and central nervous systems might be target antigens, but further investigations will be needed to clarify the precise pathogenic mechanisms.
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Registered trials
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