Evidence map›Paper›PMID 29540622›Full record

ArticleJournal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi2018

β-Adrenoceptor subtypes and cAMP role in adrenaline- and noradrenaline-induced relaxation in the rat thoracic aorta.

Shunsuke Shiina, Ayaka Kanemura, Chihiro Suzuki, Fumiko Yamaki, Keisuke Obara, Daisuke Chino, Yoshio Tanaka

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Sympathetic Nervous System and Atherosclerosis.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Shunsuke ShiinaDepartment of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi-City, Chiba 274-8510, Japan.
Ayaka KanemuraDepartment of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi-City, Chiba 274-8510, Japan.
Chihiro SuzukiDepartment of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi-City, Chiba 274-8510, Japan.
Fumiko YamakiDepartment of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi-City, Chiba 274-8510, Japan.
Keisuke ObaraDepartment of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi-City, Chiba 274-8510, Japan.
Daisuke ChinoDepartment of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi-City, Chiba 274-8510, Japan.
Yoshio TanakaDepartment of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi-City, Chiba 274-8510, Japan.
Toho University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Object We identified the β-adrenoceptor (β-AR) subtypes responsible for the relaxant responses to adrenaline (AD) and noradrenaline (NA) in the rat thoracic aorta and examined the role of cAMP which is involved in these relaxant responses. Methods The effects of β-AR antagonists or the adenylyl cyclase inhibitor SQ 22,536 on AD- and NA-induced relaxant responses in phenylephrine-induced contraction and increases in cAMP levels were examined in isolated, endothelium-denuded rat thoracic aorta segments. Results AD-induced relaxation was completely suppressed by propranolol (10

Indexed as

Adrenergic alpha-AgonistsAdrenergic beta-AgonistsAnimalsAorta, ThoracicCyclic AMPEpinephrineMaleMuscle RelaxationNorepinephrineRatsRats, WistarReceptors, Adrenergic, beta-1Receptors, Adrenergic, beta-2Signal TransductionAdrenergic alpha-AgonistsAdrenergic beta-AgonistsCyclic AMPEpinephrineNorepinephrineReceptors, Adrenergic, beta-1Receptors, Adrenergic, beta-2catecholaminesrat thoracic aortarelaxationtissue cyclic AMP levelβ-adrenoceptor (β-AR)

Identifiers

PMID29540622
PMCPMC5863045
OpenAlexW2789816100

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.