Evidence map›Paper›PMID 29540505›Full record

ArticleDevelopment (Cambridge, England)2018

A quantitative method for staging mouse embryos based on limb morphometry.

Marco Musy, Kevin Flaherty, Jelena Raspopovic, Alexandre Robert-Moreno, Joan T Richtsmeier, James Sharpe

Registry-linked trialAbstract read
In one paragraph

Article in Development (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03025763 (Craniosynostosis Network), which is not on this map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03025763 active not recruitingnot on this map

Craniosynostosis Network

TypeobservationalSponsorIcahn School of Medicine at Mount SinaiRan2015 to 2028Enrolled2,145ConditionsCraniosynostosisArmsCraniosynostosis Network Environmental Survey, 2D/3D Photography, Buccal Swab Cell Sampling, Blood sampling, Skin Biopsy
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 41 citations in OpenAlex.

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  11. Lysosomal reduced thiols are essential for mouse embryonic development.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Article
  13. Embryonic cranial cartilage defects in the Fgfr3Anatomical record (Hoboken, N.J. : 2007) · 2025
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  14. Article
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  18. Palatal segment contributions to midfacial anterior-posterior growth.bioRxiv : the preprint server for biology · 2024
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  19. Loss of the long form of Plod2 phenocopies contractures of Bruck syndrome-osteogenesis imperfecta.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Marco MusyCentre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology Dr. Aiguader 88, Barcelona 08003, Spain marco.musy@embl.es james.sharpe@embl.es.ORCID 0000-0002-3364-8909
Kevin FlahertyDepartment of Anthropology, Pennsylvania State University, University Park, PA 16802, USA.ORCID 0000-0003-2657-1314
Jelena RaspopovicCentre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology Dr. Aiguader 88, Barcelona 08003, Spain.
Alexandre Robert-MorenoCentre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology Dr. Aiguader 88, Barcelona 08003, Spain.ORCID 0000-0001-9042-1316
Joan T RichtsmeierDepartment of Anthropology, Pennsylvania State University, University Park, PA 16802, USA.ORCID 0000-0002-0239-5822
James SharpeCentre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology Dr. Aiguader 88, Barcelona 08003, Spain marco.musy@embl.es james.sharpe@embl.es.ORCID 0000-0002-1434-9743
Universitat Pompeu Fabra · ESPennsylvania State University · USInstitució Catalana de Recerca i Estudis Avançats · ES

Funding

Project III: Systems Biology of Bone in Coronal Nonsyndromic CraniosynostosisP01HD078233 · NICHD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DREW, PATRICK JAMES, JABS, ETHYLIN WANG · 2014 to 2019
$7.0M
Midface and Upper Airway in CraniosynostosisR01DE022988 · NIDCR · PENNSYLVANIA STATE UNIVERSITY, THE · PI JABS, ETHYLIN WANG, RICHTSMEIER, JOAN THERESE · 2012 to 2016
$3.1M
NICHD NIH HHS P01 HD078233NIDCR NIH HHS R01 DE022988
6 · The paper itself

Abstract

To determine the developmental stage of embryonic mice, we apply a geometric morphometric approach to the changing shape of the mouse limb bud as it grows from embryonic day 10 to embryonic day 15 post-conception. As the ontogenetic sequence results in the

Indexed as

Gestational AgeAlgorithmsAnimalsEmbryo, MammalianGene Expression Regulation, DevelopmentalHindlimbLimb BudsMiceMorphogenesiseMOSSLimb growthMorphometricsMouse developmentOsterixSonic hedgehogStaging system

Identifiers

PMID29540505
PMCPMC5963863
OpenAlexW2789886678

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.