ArticleThe Journal of biological chemistry2018
Structural basis for the catalytic mechanism and α-ketoglutarate cooperativity of glutamate dehydrogenase.
Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 53 citations in OpenAlex.
- Glutamate dehydrogenases in fungi: From biology to biotechnology.Fungal biology and biotechnology · 2026Review
- CryoEM and crystal structure analyses reveal the indirect role played by Trp89 in glutamate dehydrogenase enzymatic reactions.The FEBS journal · 2025Article
- Conformational flexibility associated with remote residues regulates the kinetic properties of glutamate dehydrogenase.Protein science : a publication of the Protein Society · 2025Article
- Integrated transcriptomic and metabolic profiling reveals the molecular mechanism of improved nitrogen metabolism in walnut (Frontiers in plant science · 2025Article
- Transcriptome and Metabolome Reveal the Molecular Mechanism of Barley Genotypes Underlying the Response to Low Nitrogen and Resupply.International journal of molecular sciences · 2023Article
- Quantifying Reductive Amination in Nonenzymatic Amino Acid Synthesis.Angewandte Chemie (International ed. in English) · 2022Article
- A counter-enzyme complex regulates glutamate metabolism in Bacillus subtilis.Nature chemical biology · 2022Article
- Nitrogen Availability Affects the Metabolic Profile in Cyanobacteria.Metabolites · 2021Article
- Comparative Analysis of Proteins of Functionally Different Body Parts of the Fish Parasites Triaenophorus nodulosus and Triaenophorus crassus.Acta parasitologica · 2021Article
- Temperature-induced reorganisation of Schistocephalus solidus (Cestoda) proteome during the transition to the warm-blooded host.Biology open · 2021Article
- Simultaneous directed evolution of coupled enzymes for efficient asymmetric synthesis ofApplied and environmental microbiology · 2021Article
- The Role of Pi, Glutamine and the Essential Amino Acids in Modulating the Metabolism in Diabetes and Cancer.Journal of diabetes and metabolic disorders · 2020Review
- Recombinant l-glutaminase obtained fromRSC advances · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glutamate dehydrogenase (GDH) is a key enzyme connecting carbon and nitrogen metabolism in all living organisms. Despite extensive studies on GDHs from both prokaryotic and eukaryotic organisms in the last 40 years, the structural basis of the catalytic features of this enzyme remains incomplete. This study reports the structural basis of the GDH catalytic mechanism and allosteric behavior. We determined the first high-resolution crystal structures of glutamate dehydrogenase from the fungus
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