Evidence map›Paper›PMID 29540225›Full record

ArticleReproductive health2018

Community approval required for periconceptional adolescent adherence to weekly iron and/or folic acid supplementation: a qualitative study in rural Burkina Faso.

Adélaïde Compaoré, Sabine Gies, Bernard Brabin, Halidou Tinto, Loretta Brabin

Registry-linked trialAbstract readComparative Study
In one paragraph

Article in Reproductive health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01210040 (Malaria Risk Prior to and During Early Pregnancy in Nulliparous Women Receiving Long-term Weekly Iron and Folic Acid Supplementation), which is not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01210040 nacompletednot on this map

Malaria Risk Prior to and During Early Pregnancy in Nulliparous Women Receiving Long-term Weekly Iron and Folic Acid Supplementation (WIFS): a Non-inferiority Randomized Controlled Trial

TypeinterventionalSponsorLiverpool School of Tropical MedicineRan2011 to 2014Enrolled1,959ConditionsMalariaArmsFolic Acid, Folic Acid and Iron
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Adélaïde CompaoréClinical Research Unit Nanoro, Institut de Recherche en Sciences de la, Santé, Direction Régionale du Centre-Ouest, Nanoro, Burkina Faso.
Sabine GiesDepartment of Biomedical Sciences, Prince Leopold Institute of Tropical Medicine, Antwerp, Belgium.
Bernard BrabinLiverpool School of Tropical Medicine and Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom; Global Child Health Group, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
Halidou TintoClinical Research Unit Nanoro, Institut de Recherche en Sciences de la, Santé, Direction Régionale du Centre-Ouest, Nanoro, Burkina Faso.
Loretta BrabinDivision of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. loretta.brabin@manchester.ac.uk.ORCID http://orcid.org/0000-0003-4478-6503

Funding

Long-term WIFS and malaria risk in early pregnancy: a randomized controlled trialU01HD061234 · NICHD · TMLIVERPOOL SCHOOL OF TROPICAL MEDICINE · PI BRABIN, BERNARD JOHN · 2009 to 2014
$1.9M
National Institute of Child Health and Human Development Grant Number U01HD061234-01A1; Supplementary -05S1 and -02S2National Institutes of Health Grant Number U01HD061234-01A1; Supplementary -05S1 and -02S2National Institutes of Health Office of Dietary Supplements U01HD061234-01A1; Supplementary -05S1 and -02S2NICHD NIH HHS U01 HD061234
6 · The paper itself

Abstract

backgroundIron deficiency remains a prevalent adolescent health problem in low income countries. Iron supplementation is recommended but improvement of iron status requires good adherence.

objectivesWe explored factors affecting adolescent adherence to weekly iron and/or folic acid supplements in a setting of low secondary school attendance.

methodsTaped in-depth interviews were conducted with participants in a randomised, controlled, periconceptional iron supplementation trial for young nulliparous women living in a rural, malaria endemic region of Burkina Faso. Participants with good, medium or poor adherence were selected. Interviews were transcribed and analysed thematically.

resultsThirty-nine interviews were conducted. The community initially thought supplements were contraceptives. The potential benefits of giving iron supplementation to unmarried "girls" ahead of pregnancy were not recognised. Trial participation, which required parental consent, remained high but was not openly admitted because iron supplements were thought to be contraceptives. Unmarried non-school attenders, being mobile, were often sent to provide domestic labour in varied locations. This interrupted adherence - as did movement of school girls during vacations and at marriage. Field workers tracked participants and trial provision of free treatment encouraged adherence. Most interviewees did not identify health benefits from taking supplements.

conclusionsFor success, communities must be convinced of the value of an adolescent intervention. During this safety trial, benefits not routinely available in iron supplementation programmes were important to this low income community, ensuring adolescent participation. Nevertheless, adolescents were obliged to fulfil cultural duties and roles that interfered with regular adherence to the iron supplementation regime.

trial registrationTrial Registration at clinicaltrials.gov : NCT01210040.

Indexed as

Adolescent Nutritional Physiological PhenomenaDietary SupplementsPatient CompliancePreconception CareRural HealthAdolescentAnemia, Iron-DeficiencyBurkina FasoCohort StudiesCulturally Competent CareDeveloping CountriesFemaleFocus GroupsFolic AcidFollow-Up StudiesHumansFolic AcidIron, DietaryAdherenceAdolescentsBurkina FasoIron supplementationNon-pregnantPregnantQualitative

Identifiers

PMID29540225
PMCPMC5852966

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.