Evidence map›Paper›PMID 29540166›Full record

ArticleBMC medical genetics2018

HRG C633T polymorphism and risk of gestational hypertensive disorders: a pilot study.

Evangelia Elenis, Alkistis Skalkidou, Agneta Skoog-Svanberg, Gunilla Sydsjö, Anneli Stavreus-Evers, Helena Åkerud

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medical genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Evangelia ElenisDepartment of Women's and Children's Health, Uppsala University, -751 85, Uppsala, SE, Sweden. evangelia.elenis@kbh.uu.se.ORCID 0000-0002-2253-4682
Alkistis SkalkidouDepartment of Women's and Children's Health, Uppsala University, -751 85, Uppsala, SE, Sweden.
Agneta Skoog-SvanbergDepartment of Women's and Children's Health, Uppsala University, -751 85, Uppsala, SE, Sweden.
Gunilla SydsjöObstetrics and gynaecology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
Anneli Stavreus-EversDepartment of Women's and Children's Health, Uppsala University, -751 85, Uppsala, SE, Sweden.
Helena ÅkerudDepartment of Women's and Children's Health, Uppsala University, -751 85, Uppsala, SE, Sweden.
Uppsala University · SELinköping University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPreeclampsia and gestational hypertensive disorders are thought to occur due to endothelial cell dysfunction and abnormal placentation, triggered by angiogenesis-related factors yet undetermined. The aim of this study was to investigate whether a genetic polymorphism (SNP) of Histidine-rich glycoprotein (HRG), HRG C633T SNP, is associated with gestational hypertensive disorders.

methodsIt was performed a nested case-control study from the BASIC Cohort of Uppsala University Hospital comprising 92 women diagnosed with gestational hypertensive disorders without other comorbidities and 200 women with full term uncomplicated pregnancies, all genotyped regarding HRG C633T SNP.

resultsThe genetic analysis of the study sample showed that C/C genotype was more prevalent among controls. The presence of the T-allele showed a tendency towards an increased risk of gestational hypertensive disorders. After clustering the study participants based on their genotype, it was observed that the odds for gestational hypertensive disorders among heterozygous C/T or homozygous T/T carriers were higher compared to homozygous C/C carriers [OR 1.72, 95% CI (1.04-2.84)]. The association remained significant even after adjustment for maternal age, BMI and parity.

conclusionsThe HRG C633T genotype seems to be associated with gestational hypertensive disorders, and as part of a greater algorithm, might contribute in the future to the prediction of the individual susceptibility to the condition.

Indexed as

Polymorphism, Single NucleotideAdultAllelesBody Mass IndexCase-Control StudiesCohort StudiesFemaleGenotypeHeterozygoteHistidine-Rich GlycoproteinHomozygoteHumansHypertension, Pregnancy-InducedLogistic ModelsPilot ProjectsPregnancyHistidine-Rich GlycoproteinProteinsAngiogenesisGestational hypertensive disordersHRGHRG C633T SNPPreeclampsia

Identifiers

PMID29540166
PMCPMC5853153
OpenAlexW2790562502

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.