ArticlePharmaceutical biology2018
Crocin exerts anti-inflammatory and anti-arthritic effects on type II collagen-induced arthritis in rats.
Article in Pharmaceutical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Efficacy and safety of dietary polyphenols in rheumatoid arthritis: A systematic review and meta-analysis of 47 randomized controlled trials.Frontiers in immunology · 2023Pooled it
- Exploring the therapeutic potential of crocin, a bioactive component of saffron, in neurocognitive deficit and pulmonary impairment induced by inhalational exposure to petroleum vapours.Molecular biology reports · 2026Article
- Immunomodulatory effects of medicinal and edible plants in autoimmune diseases: mechanisms and therapeutic potential.Frontiers in immunology · 2026Review
- Carotenoids and Their Interaction with the Immune System.Antioxidants (Basel, Switzerland) · 2025Review
- The Combined Effect of Curcumin and Crocin on the Reduction of Inflammatory Responses in Arthritic Rats.Current medicinal chemistry · 2024Article
- Liquiritigenin, isoliquiritigenin rich extract of glycyrrhiza glabra roots attenuates inflammation in macrophages and collagen-induced arthritis in rats.Inflammopharmacology · 2023Article
- Article
- Review
- Crocin restores the balance of Th1/Th2 immune cell response in ConA-treated human lymphocytes.Pharmacological reports : PR · 2022Article
- Circulating Human Serum Metabolites Derived from the Intake of a Saffron Extract (Safr'InsideNutrients · 2022Article
- In vivo and in vitro efficacy of crocin against Echinococcus multilocularis.Parasites & vectors · 2021Article
- Effects of metal nanoparticles on tight junction-associated proteins via HIF-1α/miR-29b/MMPs pathway in human epidermal keratinocytes.Particle and fibre toxicology · 2021Article
- Electroacupuncture Synergistically Inhibits Proinflammatory Cytokine Production and Improves Cognitive Function in Rats with Cognitive Impairment due to Hepatic Encephalopathy through p38MAPK/STAT3 and TLR4/NF-Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Therapeutic Potential of Saffron (Evidence-based complementary and alternative medicine : eCAM · 2021Review
- Crocin Improves Endothelial Mitochondrial DysfunctionFrontiers in cell and developmental biology · 2021Article
- The Effects of Crocin on Bone and Cartilage Diseases.Frontiers in pharmacology · 2021Review
- Baicalin alleviates collagen‑induced arthritis and suppresses TLR2/MYD88/NF‑κB p65 signaling in rats and HFLS‑RAs.Molecular medicine reports · 2020Article
- Molecular Targets of Natural Products for Chondroprotection in Destructive Joint Diseases.International journal of molecular sciences · 2020Review
- Prospects and progress on crocin biosynthetic pathway and metabolic engineering.Computational and structural biotechnology journal · 2020Review
- Crocin enhances the viability of random pattern skin flaps: involvement of enhancing angiogenesis and inhibiting oxidative stress.American journal of translational research · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextRheumatoid arthritis (RA) is a common systemic auto-immune disease, which is characterized by chronic and symmetry synovial inflammation. Crocin has been reported to exhibit anti-inflammatory effects in animal models.
objectiveThis study investigates the anti-inflammatory and anti-arthritic effects of crocin on type II collagen-induced arthritis (CIA) in Wistar rats. MATERIALS AND
methodsThe CIA rat model was established and randomly divided into five groups with or without crocin treatment (10, 20 or 40 mg/kg), which was started on day 21 after arthritis induction and persisted for 36 days. The symptoms and molecular mechanisms of CIA and crocin-treated CIA rats were compared and investigated.
resultsCIA rats presented severe RA symptoms, including high arthritis score, paw swelling, joint inflammation, bone erosion, chondrocyte death, cartilage destruction, enhanced expressions of matrix metalloproteinase (MMP) and pro-inflammatory cytokines. However, crocin could mitigate these symptoms. Crocin (40 mg/kg) exhibited the most efficient therapeutic function on CIA rats: the histological scores of joint inflammation, bone erosion, chondrocyte death, cartilage surface erosion, and bone erosion of CIA rats receiving 40 mg/kg crocin treatment were comparable to the normal rats. MMP-1, -3 and -13 protein expression levels of CIA rats with 40 mg/kg crocin treatment were decreased to levels similar to normal rats. Moreover, crocin could also inhibit the expression of TNF-α, IL-17, IL-6 and CXCL8 in serum and ankle tissues of CIA rats.
conclusionsIn summary, crocin exhibits therapeutic potential for RA, by mitigating the symptoms and inhibiting the pro-inflammatory factor expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.