SynthesisBiological research for nursing2018
A Systematic Review of Biological Mechanisms of Fatigue in Chronic Illness.
Synthesis in Biological research for nursing, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 4 syntheses or guidelines pooled it, 136 citations in OpenAlex.
- Effectiveness of non-pharmacological interventions for fatigue in adults with long-term conditions: a synopsis of the EIFFEL mixed-methods evidence synthesis.Health technology assessment (Winchester, England) · 2026Pooled it
- Is there a role for traditional and complementary medicines in managing chronic fatigue? a systematic review of randomized controlled trials.Frontiers in pharmacology · 2023Pooled it
- Fatigue severity and avoidance among individuals with chronic disease: A meta-analysis.Journal of psychosomatic research · 2022Pooled it
- A systematic review of the association between fatigue and cognition in chronic noncommunicable diseases.Chronic illness · 2021Pooled it
- Randomized investigation of increased dialyzer membrane hydrophilicity on hemocompatibility and performance.BMC nephrology · 2024Trial
- Somatosensory processing in long COVID fatigue and its relations with physiological and psychological factors.Experimental physiology · 2026Article
- Behavioral and molecular characterization of fatigue-like manifestations triggered by acute restraint stress and LPS or saline.Scientific reports · 2026Article
- Effects of Rosa roxburghii and kiwifruit composite supplements on improving exercise performance and anti-fatigue in mice.Scientific reports · 2026Article
- A mouse model to study persistent fatigue.Research square · 2026Article
- Evaluating the Longitudinal Association of Rheumatoid Arthritis Disease Activity With Phenotypic Frailty: Evidence for Secondary Frailty?Arthritis care & research · 2026Article
- Characteristics of gut microbiota and metabolites in patients with ulcerative colitis with fatigue.World journal of gastroenterology · 2026Article
- Study on the Anti-fatigue Effects of Polysaccharides from Erjing Formula.Current pharmaceutical biotechnology · 2026Article
- Machine learning to predict postdialysis fatigue in patients undergoing hemodialysis.Renal failure · 2025Article
- Decreased Heart Rate Variability Is Associated with Increased Fatigue Across Different Medical Populations: A Systematic Review.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025Review
- Validation of the cancer fatigue scale (CFS) in a UK population.BMC cancer · 2025Article
- Twenty years of research on exercise-induced fatigue: A bibliometric analysis of hotspots, bursts, and research trends.Medicine · 2025Article
- Progress in Preparation Technology and Functional Research On Marine Bioactive Peptides.Marine biotechnology (New York, N.Y.) · 2025Review
- Anti-Fatigue Activity of Corn Protein Hydrolysate Fermented by Lactic Acid Bacteria.Nutrients · 2025Article
- Fatigue, interoplastic and nociplastic distress in myalgic encephalomyelitis/chronic fatigue syndrome, Gulf War Illness, and chronic idiopathic fatigue.Frontiers in neuroscience · 2025Article
- Associations Between Fatigue and Cardiovascular-Kidney-Metabolic Syndrome and the Mediating Role of Inflammation.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Fatigue, a commonly reported symptom, is defined as an overwhelming, debilitating, and sustained sense of exhaustion that decreases the ability to function and carry out daily activities. To date, cancer researchers have been in the forefront in investigating the possible biological mechanisms of fatigue, identifying inflammation, dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, and activation of the autonomic nervous system. The purpose of this systematic review is to describe fatigue and what is known about the biological mechanisms described in cancer in five chronic, noninfectious illnesses: heart failure, multiple sclerosis, chronic kidney disease, rheumatoid arthritis, and chronic obstructive pulmonary disease. We searched PubMed and EMBASE using fatigue as a major Medical subject headings (MeSH) heading with each individual disease added as a search term followed by each biological mechanism. We included only primary research articles published in English between 1996 and 2016 describing studies conducted in adult humans. We identified 26 relevant articles. While there is some evidence that the biological mechanisms causing fatigue in cancer are also associated with fatigue in other chronic illnesses, more research is needed to explore inflammation, the HPA axis, and the autonomic nervous system, and other mechanisms in relation to fatigue in a variety of chronic illnesses.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.