ArticleNature2018
DNA methylation-based classification of central nervous system tumours.
2 registry-linked trialsAbstract read
In one paragraph
Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 1,793 papers, 3 of them syntheses that pooled it.
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1,793citing papers in PubMed, 3 pooled it
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Development of a Comprehensive Predictive Model for Risk of Metastatic Disease in PPGLs Based on a Combination of Clinical, Biochemical, Genetic, and Pathoanatomical Characteristics a Retrospective National Cohort Study
PaCIFiC-CUP：Pan-Cancer Integrated Fingerprinting Classifier for Identifying the Origin of Cancer of Unknown Primary: A Multi-Center Prospective Cohort Study
Who cites it
1,793 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Pooled it
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- Gliomas with pleomorphic and pseudopapillary features (GPAP) are circumscribed tumors with targetable mutations, prolonged survival, and frequent tumor predisposition.Brain pathology (Zurich, Switzerland) · 2026Article
- Functional proteomic and phosphoproteomic profiling of routine FFPE CNS tumor tissue complements genomic and epigenomic characterization.Acta neuropathologica · 2026Article
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- Contemporary Profile of Hybrid Nerve Sheath Tumors: Clinical, Anatomical, and Imaging Characteristics.Cancers · 2026Article
- "Updates on diagnostic and prognostic molecular biomarkers of CNS tumors".Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Review
- Complementary use of the DNA methylation-based tumor classification by the Bethesda v3 classifier in routine diagnostics: evaluation in a series of 516 cases.Acta neuropathologica · 2026Article
- CpG hypermethylation and WNT/AP-1 cooperativity define the epigenetic landscape and a clinical subgroup of high-risk pediatric adrenocortical carcinoma.Nature communications · 2026Article
- Methylation profiling in CNS tumor diagnostics: a single-centre real-world experience from Central Europe.Virchows Archiv : an international journal of pathology · 2026Article
- Clinical evaluation of the CrossNN DNA methylation classifier for central nervous system tumors.Brain pathology (Zurich, Switzerland) · 2026Article
- From Anatomy to Outcome: Linking Glioma Location Patterns to Survival Using Non-Negative Matrix Factorization.Clinical neuroradiology · 2026Article
- Genomic hallmarks of depot medroxyprogesterone acetate-associated meningiomas.Neuro-oncology · 2026Article
- Molecular and clinical features of a Japanese medulloblastoma cohort: Subgroup-specific prognostic stratification using economical/accessible diagnostic methods.Brain pathology (Zurich, Switzerland) · 2026Article
1,733 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
143 authors.
David CapperDepartment of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.
David T W JonesHopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.
Martin SillHopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.
Volker HovestadtDivision of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Daniel SchrimpfDepartment of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.
Dominik SturmHopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.
Christian KoelscheDepartment of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.
Felix SahmDepartment of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.
Lukas ChavezHopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.
David E ReussDepartment of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.
Annekathrin KratzDepartment of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.
Annika K WefersDepartment of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.
Kristin HuangDepartment of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.
Kristian W PajtlerHopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.
Leonille SchweizerDepartment of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.
Damian StichelDepartment of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.
Adriana OlarDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA.
Nils W EngelDepartment of Oncology and Hematology with Sections Bone Marrow Transplant and Pneumology, Hubertus Wald Tumorzentrum/University Cancer Center Hamburg, University Medical Center Hamburg, Hamburg, Germany.
Kerstin LindenbergClinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Patrick N HarterInstitute of Neurology (Edinger Institute), Goethe-University Frankfurt am Main, Frankfurt am Main, Germany.
Anne K BraczynskiInstitute of Neurology (Edinger Institute), Goethe-University Frankfurt am Main, Frankfurt am Main, Germany.
Karl H PlateInstitute of Neurology (Edinger Institute), Goethe-University Frankfurt am Main, Frankfurt am Main, Germany.
Hildegard DohmenInstitute of Neuropathology, University of Giessen, Giessen, Germany.
Boyan K GarvalovInstitute of Neuropathology, University of Giessen, Giessen, Germany.
Roland CorasNeuropathological Institute, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany.
Annett HölskenNeuropathological Institute, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany.
Ekkehard HewerInstitute of Pathology, University of Bern, Bern, Switzerland.
Melanie Bewerunge-HudlerGenomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Matthias SchickGenomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Roger FischerGenomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Rudi BeschornerInstitute of Pathology and Neuropathology, Department of Neuropathology, University Hospital Tübingen, Tübingen, Germany.
Jens SchittenhelmInstitute of Pathology and Neuropathology, Department of Neuropathology, University Hospital Tübingen, Tübingen, Germany.
Ori StaszewskiInstitute of Neuropathology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
Khalida WaniDepartment of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Pascale VarletDepartment of Neuropathology, Centre Hospitalier Sainte Anne, Paris, France.
Melanie PagesDepartment of Neuropathology, Centre Hospitalier Sainte Anne, Paris, France.
Petra TemmingPediatrics III, Pediatric Oncology and Hematology, University Hospital Essen, Essen, Germany.
Dietmar LohmannEye Cancer Research Group, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany.
Florian SeltHopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.
Hendrik WittHopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.
Till MildeHopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.
Olaf WittHopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.
Eleonora AronicaDepartment of (Neuro)Pathology, Academic Medisch Centrum (AMC), University of Amsterdam, Amsterdam, The Netherlands.
Felice GiangasperoDepartment of Radiological, Oncological and Anatomo-Pathological Sciences, Sapienza University, Rome, Italy.
Elisabeth RushingDepartment of Neuropathology, University Hospital Zurich, Zurich, Switzerland.
Wolfram ScheurlenCnopf'sche Kinderklinik Nuremberg, Nuremberg, Germany.
Christoph GeisenbergerDepartment of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany.
Fausto J RodriguezDivision of Neuropathology of the Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Albert BeckerDepartment of Neuropathology, University of Bonn, Bonn, Germany.
Matthias PreusserDepartment of Medicine I, Comprehensive Cancer Center Vienna, CNS Unit (CCC-CNS), Medical University of Vienna, Vienna, Austria.
Christine HaberlerInstitute of Neurology, Medical University of Vienna, Vienna, Austria.
Rolf BjerkvigDepartment of Biomedicine, University of Bergen, Bergen, Norway.
Jane CryanDepartment of Neuropathology, Beaumont Hospital, Dublin, Ireland.
Michael FarrellDepartment of Neuropathology, Beaumont Hospital, Dublin, Ireland.
Martina DeckertDepartment of Neuropathology, University Hospital of Cologne, Cologne, Germany.
Jürgen HenchDepartment of Neuropathology, Institute of Pathology, Basel University Hospital, Basel, Switzerland.
Stephan FrankDepartment of Neuropathology, Institute of Pathology, Basel University Hospital, Basel, Switzerland.
Jonathan SerranoNYU Langone Medical Center, New York, New York, USA.
Kasthuri KannanNYU Langone Medical Center, New York, New York, USA.
Aristotelis TsirigosNYU Langone Medical Center, New York, New York, USA.
Wolfgang BrückInstitute of Neuropathology, University Medical Center Göttingen, Göttingen, Germany.
Silvia HoferDivision of Oncology, Luzerner Kantonsspital, Luzern, Switzerland.
Stefanie BrehmerDepartment of Neurosurgery, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
Marcel Seiz-RosenhagenDepartment of Neurosurgery, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
Daniel HänggiDepartment of Neurosurgery, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
Volkmar HansInstitut für Neuropathologie, Evangelisches Krankenhaus Bielefeld gGmbH, Bielefeld, Germany.
Stephanie RozsnokiInstitute of Neuropathology, University Hospital Münster, Münster, Germany.
Jordan R HansfordChildren's Cancer Centre, Royal Children's Hospital, University of Melbourne, Melbourne, Victoria, Australia.
Patricia KohlhofInstitute for Pathology, Katharinenhospital Stuttgart, Stuttgart, Germany.
Bjarne W KristensenDepartment of Pathology, Odense University Hospital, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Matt LechnerUniversity College London Cancer Institute and University College London Hospitals, London, UK.
Beatriz LopesDepartment of Pathology, University of Virginia, Charlottesville, Virginia, USA.
Christian MawrinInstitute of Neuropathology, Otto-von-Guericke-University, Magdeburg, Germany.
Ralf KetterDepartment of Neurosurgery, University Hospital Saarland, Homburg, Saar, Germany.
Andreas KulozikHopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.
Ziad KhatibNicklaus Children's Hospital Brain Institute, Miami, Florida 33155, USA.
Frank HeppnerCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Neuropathology, Berlin, Germany.
Arend KochCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Neuropathology, Berlin, Germany.
Anne JouvetDépartement de Pathologie et Neuropathologie, Hôpital Neurologique, Hospices Civils de Lyon, Lyon, France.
Catherine KeohaneDepartment of Neuropathology, Cork University Hospital, Cork, Ireland.
Helmut MühleisenDepartment of Pathology, Ludwigsburg Hospital, Ludwigsburg, Germany.
Wolf MuellerDepartment of Neuropathology, Leipzig University, Leipzig, Germany.
Ute PohlDepartment of Cellular Pathology, Queen's Hospital, Romford, UK.
Marco PrinzInstitute of Neuropathology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
Axel BennerDivision of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Marc ZapatkaDivision of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Nicholas G GottardoDepartment of Pediatric Oncology and Haematology, Princess Margaret Hospital for Children, GPO Box D184, Perth, Western Australia 6840, Australia.
Pablo Hernáiz DrieverDepartment of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Christof M KrammDivision of Pediatric Hematology and Oncology, University Medical Center Göttingen, Göttingen, Germany.
Hermann L MüllerDepartment of Pediatrics and Pediatric Hematology/Oncology, Klinikum Oldenburg AöR, Medical Campus University Oldenburg, 26133 Oldenburg, Germany.
Stefan RutkowskiDepartment for Pediatric Hematology and Oncology, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
Katja von HoffDepartment of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Michael C FrühwaldChildren's Hospital Augsburg, Swabian Children's Cancer Centre, Augsburg, Germany.
Astrid GnekowChildren's Hospital Augsburg, Swabian Children's Cancer Centre, Augsburg, Germany.
Gudrun FleischhackPediatrics III, Pediatric Oncology and Hematology, University Hospital Essen, Essen, Germany.
Stephan TippeltPediatrics III, Pediatric Oncology and Hematology, University Hospital Essen, Essen, Germany.
Gabriele CalaminusDepartment of Pediatric Hematology/Oncology, University of Bonn Medical Center, Bonn, Germany.
Camelia-Maria MonoranuDepartment of Neuropathology, Insitute of Pathology, Comprehensive Cancer Center (CCC) Mainfranken, University of Würzburg, Würzburg, Germany.
Arie PerryDepartment of Pathology, University of California San Francisco, San Francisco, California, USA.
Chris JonesDivision of Molecular Pathology, Institute of Cancer Research, London, UK.
Thomas S JacquesDevelopmental Biology and Cancer Programme, UCL Great Ormond Street Institute of Child Health and Histopathology Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Bernhard RadlwimmerDivision of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Marco GessiDepartment of Neuropathology, University of Bonn, Bonn, Germany.
Torsten PietschDepartment of Neuropathology, University of Bonn, Bonn, Germany.
Johannes SchrammMedical Faculty, University of Bonn Medical School, Bonn, Germany.
Gabriele SchackertDepartment of Neurosurgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Manfred WestphalDepartment of Neurosurgery, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
Guido ReifenbergerDepartment of Neuropathology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Pieter WesselingDepartment of Pathology, Princess Máxima Center for Pediatric Oncology and University Medical Center Utrecht, Utrecht, The Netherlands.
Michael WellerDepartment of Neurology, University Hospital and University of Zurich, Zurich, Switzerland.
Vincent Peter CollinsDepartment of Pathology, Division of Molecular Histopathology, University of Cambridge, Cambridge, UK.
Ingmar BlümckeNeuropathological Institute, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany.
Martin BendszusDepartment of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
Jürgen DebusDepartment of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany.
Annie HuangDepartment of Pediatrics, Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
Nada JabadoDivision of Hematology/Oncology, McGill University, Montreal, Quebec, Canada.
Paul A NorthcottDepartment of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
Werner PaulusInstitute of Neuropathology, University Hospital Münster, Münster, Germany.
Amar GajjarDepartment of Oncology, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
Giles W RobinsonDepartment of Oncology, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
Michael D TaylorDivision of Neurosurgery, Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Zane JaunmuktaneDivision of Neuropathology, UCL Hospitals, Institute of Neurology, University College London, Queen Square, WC1N 3BG London, UK.
Marina RyzhovaNN Burdenko Neurosurgical Institute, Moscow, Russia.
Michael PlattenDepartment of Neurology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Andreas UnterbergDepartment of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany.
Wolfgang WickDepartment of Neurology, Heidelberg University Hospital, Heidelberg, Germany.
Matthias A KarajannisDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Michel MittelbronnInstitute of Neurology (Edinger Institute), Goethe-University Frankfurt am Main, Frankfurt am Main, Germany.
Till AckerInstitute of Neuropathology, University of Giessen, Giessen, Germany.
Christian HartmannDepartment of Neuropathology, Hannover Medical School (MHH), Hannover, Germany.
Kenneth AldapeDepartment of Pathology, University of Toronto, Toronto, Ontario, Canada.
Ulrich SchüllerCenter for Neuropathology and Prion Research, Ludwig-Maximilians-University, Munich, Germany.
Rolf BusleiNeuropathological Institute, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany.
Peter LichterDivision of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Marcel KoolHopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.
Christel Herold-MendeDepartment of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany.
David W EllisonDepartment of Pathology, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
Martin HasselblattInstitute of Neuropathology, University Hospital Münster, Münster, Germany.
Matija SnuderlDivision of Neuropathology, Department of Pathology, NYU Langone Medical Center, New York, New York, USA.
Sebastian BrandnerDivision of Neuropathology, UCL Hospitals, Institute of Neurology, University College London, Queen Square, WC1N 3BG London, UK.
Andrey KorshunovDepartment of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.
Andreas von DeimlingDepartment of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.
Stefan M PfisterHopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MViral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9MMultidisciplinary Subspecialty Pathology Research Fellowship ProgramT32CA163185 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI CZERNIAK, BOGDAN A, KEYOMARSI, KHANDAN · 2011 to 2015
$1.7MCancer Research UK 13982Cancer Research UK 23536Medical Research Council G0701018Medical Research Council G1100578Medical Research Council MR/N004272/1NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA021765NCI NIH HHS T32 CA163185NIH HHS 5T32CA163185
Abstract
Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challenging-with substantial inter-observer variability in the histopathological diagnosis of many tumour types. Here we present a comprehensive approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups, and demonstrate its application in a routine diagnostic setting. We show that the availability of this method may have a substantial impact on diagnostic precision compared to standard methods, resulting in a change of diagnosis in up to 12% of prospective cases. For broader accessibility, we have designed a free online classifier tool, the use of which does not require any additional onsite data processing. Our results provide a blueprint for the generation of machine-learning-based tumour classifiers across other cancer entities, with the potential to fundamentally transform tumour pathology.
Indexed as
DNA MethylationAdolescentAdultAgedAged, 80 and overCentral Nervous System NeoplasmsChildChild, PreschoolCohort StudiesFemaleHumansInfantMaleMiddle AgedReproducibility of ResultsUnsupervised Machine Learning
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Registered trials
NCT04788927ClinicalTrials.gov
NCT06140992ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.