ArticleNature2018
Integrative structure and functional anatomy of a nuclear pore complex.
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In one paragraph
Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 297 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
297citing papers in PubMed, 1 pooled it
27.6field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
297 citing papers in PubMed, 1 synthesis or guideline pooled it, 543 citations in OpenAlex.
- Comprehensive analysis of regulated cell death pathways: intrinsic disorder, protein-protein interactions, and cross-pathway communication.Apoptosis : an international journal on programmed cell death · 2025Pooled it
- RNA export through the nuclear pore complex: pathways, mechanisms, and imaging strategies.RNA biology · 2026Review
- Expandable DNA-origami rings as a nanomechanical platform for studying disordered nucleoporins.bioRxiv : the preprint server for biology · 2026Article
- Building peroxisomes: perspectives on plant peroxins.Biochemical Society transactions · 2026Review
- Hydrophobic interactions of FG-nucleoporins are required for dilating nuclear membrane pores into selective transport channels after mitosis.Nature structural & molecular biology · 2026Article
- Mlp1 and Mlp2 cooperate to build a stoichiometric nuclear pore basket in budding yeast.Journal of cell science · 2026Article
- HIV-1 capsid interactions with Nuclear Pore Complex components support nuclear entry via affinity gradient.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Mechanoresponsive modulation of nuclear pore complex structure and function bybioRxiv : the preprint server for biology · 2026Article
- Molecular mechanisms of the MLL4 complex in H3K4 methylation and p53-dependent transcription activation.Molecular cell · 2026Article
- The nuclear envelope protein TMEM209 is an integral component of the nuclear pore complex and interacts with Nup210.Journal of cell science · 2026Article
- SuAVE-Scatter: A Module for Integrating Simulations and SAXS/SANS Analyses.Journal of chemical information and modeling · 2026Article
- A nature-inspired ion trap for parallel manipulation of ions on a massive scale.Science advances · 2026Article
- Structural basis for the recruitment and selective phosphorylation of Akt by mTORC2.Science (New York, N.Y.) · 2026Article
- Cellular quiescence uncouples the proteome from the transcriptome in neural stem cells.The EMBO journal · 2026Article
- Breaking barriers: Respiratory viral strategies targeting the host's nuclear pore complex and nuclear transport pathways.Molecular biology of the cell · 2026Review
- Structure, function and assembly of nuclear pore complexes.Nature reviews. Molecular cell biology · 2026Review
- Kap-centric Nsp1-mediated nuclear transport at full amino acid resolution.Nature communications · 2025Article
- Viral interference of nucleocytoplasmic transport.The Journal of biological chemistry · 2025Review
- Karyopherins remodel the dynamic organization of the nuclear pore complex transport barrier.Nature cell biology · 2025Article
- Elucidating the nanoscopic organization and dynamics of the nuclear pore complex.Nucleus (Austin, Tex.) · 2025Article
237 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
32 authors at 11 institutions in 1 country.
Seung Joong KimDepartment of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Chemistry, and California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, California 94158, USA.
Javier Fernandez-MartinezLaboratory of Cellular and Structural Biology, The Rockefeller University, New York, New York 10065, USA.
Ilona NudelmanLaboratory of Cellular and Structural Biology, The Rockefeller University, New York, New York 10065, USA.
Yi ShiLaboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, New York 10065, USA.
Wenzhu ZhangLaboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, New York 10065, USA.
Barak RavehDepartment of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Chemistry, and California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, California 94158, USA.
Thurston HerricksInstitute for Systems Biology, 401 Terry Ave. N., Seattle, Washington 98109, USA.
Brian D SlaughterStowers Institute for Medical Research, Kansas City, Missouri 64110, USA.
Joanna A HoganDepartment of Chemistry, Indiana University, Bloomington, Indiana 47405, USA.
Paula UplaSkirball Institute and Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA.
Ilan E ChemmamaDepartment of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Chemistry, and California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, California 94158, USA.
Riccardo PellarinDepartment of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Chemistry, and California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, California 94158, USA.
Ignacia EcheverriaDepartment of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Chemistry, and California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, California 94158, USA.
Manjunatha ShivarajuStowers Institute for Medical Research, Kansas City, Missouri 64110, USA.
Azraa S ChaudhuryLaboratory of Cellular and Structural Biology, The Rockefeller University, New York, New York 10065, USA.
Junjie WangLaboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, New York 10065, USA.
Rosemary WilliamsLaboratory of Cellular and Structural Biology, The Rockefeller University, New York, New York 10065, USA.
Jay R UnruhStowers Institute for Medical Research, Kansas City, Missouri 64110, USA.
Charles H GreenbergDepartment of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Chemistry, and California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, California 94158, USA.
Erica Y JacobsLaboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, New York 10065, USA.
Zhiheng YuJanelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, Virginia 20148, USA.
M Jason de la CruzJanelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, Virginia 20148, USA.
Roxana MironskaLaboratory of Cellular and Structural Biology, The Rockefeller University, New York, New York 10065, USA.
David L StokesSkirball Institute and Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA.
John D AitchisonInstitute for Systems Biology, 401 Terry Ave. N., Seattle, Washington 98109, USA.
Martin F JarroldDepartment of Chemistry, Indiana University, Bloomington, Indiana 47405, USA.
Jennifer L GertonStowers Institute for Medical Research, Kansas City, Missouri 64110, USA.
Steven J LudtkeVerna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA.
Christopher W AkeyDepartment of Physiology and Biophysics, Boston University School of Medicine, 700 Albany Street, Boston, Massachusetts 02118, USA.
Brian T ChaitLaboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, New York 10065, USA.
Andrej SaliDepartment of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Chemistry, and California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, California 94158, USA.
Michael P RoutLaboratory of Cellular and Structural Biology, The Rockefeller University, New York, New York 10065, USA.
Rockefeller University · USQB3 · USStowers Institute for Medical Research · USUniversity of California, San Francisco · USIndiana University Bloomington · USInstitute for Systems Biology · USNew York University · USBaylor College of Medicine · USBoston University · USHelix (United States) · USHoward Hughes Medical Institute · US
Funding
Quantitative Systems BiologyP50GM076547 · NIGMS · INSTITUTE FOR SYSTEMS BIOLOGY · PI BALIGA, NITIN S · 2006 to 2016
$30.6MTR&D Project 4. The Imaging Stage: Multiscale Spatiotemporal Modeling of Macromolecular Systems in Cellular NeighborhoodsP41GM109824 · NIGMS · ROCKEFELLER UNIVERSITY · PI ROUT, MICHAEL P · 2014 to 2023
$18.8MSTRUCTURAL BIOLOGY TRAINING PROGRAMT32GM008284 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KORTEMME, TANJA · 1988 to 2022
$10.1MNational Resource for Mass Spectrom of Biological MacromoleculesP41GM103314 · NIGMS · ROCKEFELLER UNIVERSITY · PI CHAIT, BRIAN T · 2012 to 2017
$9.9MStructure-Function Mapping of the Nuclear Pore Complex-RenewalR01GM112108 · NIGMS · ROCKEFELLER UNIVERSITY · PI JOHN D. AITCHISON, MICHAEL P ROUT · 2015 to 2026
$9.1MThe Structural Basis of Protein BiogenesisR01GM045377 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AKEY, CHRISTOPHER W · 1991 to 2023
$6.4MNew Tools for Exploring the Dynamic Interactome (Renewal)U54GM103511 · NIGMS · ROCKEFELLER UNIVERSITY · PI ROUT, MICHAEL P · 2012 to 2013
$6.2MSUPPORT AND DEVELOPMENT OF EMAN FOR ELECTRON MICROSCOPY IMAGE PROCESSINGR01GM080139 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI LUDTKE, STEVEN J · 2006 to 2022
$5.4MIMP: Software for Hybrid Determination of Macromolecular Assembly StructuresR01GM083960 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SALI, ANDREJ · 2008 to 2024
$5.2MMapping the 3D Genome LandscapeU54DK107981 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ALBER, FRANK · 2015 to 2019
$4.2MSTRUCTURAL OF THE APOPTOSOME &ITS ROLE IN CELL DEATHR01GM063834 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AKEY, CHRISTOPHER W · 2001 to 2015
$3.2MMolecular Mechanisms of Chromosome Segregation in YeastR01GM080477 · NIGMS · STOWERS INSTITUTE FOR MEDICAL RESEARCH · PI GERTON, JENNIFER L · 2008 to 2012
$1.5MNIDDK NIH HHS U54 DK107981NIGMS NIH HHS P41 GM103314NIGMS NIH HHS P41 GM109824NIGMS NIH HHS P50 GM076547NIGMS NIH HHS R01 GM045377NIGMS NIH HHS R01 GM063834NIGMS NIH HHS R01 GM080139NIGMS NIH HHS R01 GM080477NIGMS NIH HHS R01 GM083960NIGMS NIH HHS R01 GM112108NIGMS NIH HHS T32 GM008284NIGMS NIH HHS U54 GM103511NIH HHS S10 OD021596
Abstract
Nuclear pore complexes play central roles as gatekeepers of RNA and protein transport between the cytoplasm and nucleoplasm. However, their large size and dynamic nature have impeded a full structural and functional elucidation. Here we determined the structure of the entire 552-protein nuclear pore complex of the yeast Saccharomyces cerevisiae at sub-nanometre precision by satisfying a wide range of data relating to the molecular arrangement of its constituents. The nuclear pore complex incorporates sturdy diagonal columns and connector cables attached to these columns, imbuing the structure with strength and flexibility. These cables also tie together all other elements of the nuclear pore complex, including membrane-interacting regions, outer rings and RNA-processing platforms. Inwardly directed anchors create a high density of transport factor-docking Phe-Gly repeats in the central channel, organized into distinct functional units. This integrative structure enables us to rationalize the architecture, transport mechanism and evolutionary origins of the nuclear pore complex.
Indexed as
Cross-Linking ReagentsMass SpectrometryModels, MolecularNuclear PoreNuclear Pore Complex ProteinsProtein StabilityProtein TransportRNA TransportSaccharomyces cerevisiaeCross-Linking ReagentsNuclear Pore Complex Proteins
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