ArticleNeoplasia (New York, N.Y.)2018
Nephronectin is Correlated with Poor Prognosis in Breast Cancer and Promotes Metastasis via its Integrin-Binding Motifs.
Article in Neoplasia (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Nephronectin Promotes Migration of the Periocular Mesenchyme via EGFR Signaling.Investigative ophthalmology & visual science · 2026Article
- Peripheral blood mononuclear cell gene expression signatures predict long-term survivorship in canine DLBCL.Scientific reports · 2026Article
- Characterisation of a COPD-associated nephronectin (The European respiratory journal · 2025Article
- The potential of cancer stem cells for personalized risk assessment and therapeutic intervention in individuals with intrahepatic cholangiocarcinoma.Discover oncology · 2024Article
- Deeply integrating latent consistent representations in high-noise multi-omics data for cancer subtyping.Briefings in bioinformatics · 2024Article
- Protein cargo in extracellular vesicles as the key mediator in the progression of cancer.Cell communication and signaling : CCS · 2024Review
- Article
- Cell type and stage specific transcriptional, chromatin and cell-cell communication landscapes in the mammary gland.Heliyon · 2023Article
- Exosomes as crucial emerging tools for intercellular communication with therapeutic potential in ovarian cancer.Future science OA · 2023Review
- Hallmarks of cancer: The insulin-like growth factors perspective.Frontiers in oncology · 2022Review
- Tumor-derived exosomal components: the multifaceted roles and mechanisms in breast cancer metastasis.Cell death & disease · 2021Review
- Nephronectin as a Matrix Effector in Cancer.Cancers · 2021Review
- MicroRNA-216b targetsInternational journal of biological sciences · 2021Article
- Nephronectin is a prognostic biomarker and promotes gastric cancer cell proliferation, migration and invasion.Histology and histopathology · 2020Article
- BRG1 Mediates Nephronectin Activation in Hepatocytes to Promote T Lymphocyte Infiltration in ConA-Induced Hepatitis.Frontiers in cell and developmental biology · 2020Article
- Antibodies against nephronectin ameliorate anti-type II collagen-induced arthritis in mice.FEBS open bio · 2020Article
- Paracellular and transcellular migration of metastatic cells through the cerebral endothelium.Journal of cellular and molecular medicine · 2019Article
- Exploring the key communicator role of exosomes in cancer microenvironment through proteomics.Proteome science · 2019Review
- Current Progresses of Exosomes as Cancer Diagnostic and Prognostic Biomarkers.International journal of biological sciences · 2019Review
- Nephronectin mediates p38 MAPK-induced cell viability via its integrin-binding enhancer motif.FEBS open bio · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 9 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most cancer patients with solid tumors who succumb to their illness die of metastatic disease. While early detection and improved treatment have led to reduced mortality, even for those with metastatic cancer, some patients still respond poorly to treatment. Understanding the mechanisms of metastasis is important to improve prognostication, to stratify patients for treatment, and to identify new targets for therapy. We have shown previously that expression of nephronectin (NPNT) is correlated with metastatic propensity in breast cancer cell lines. In the present study, we provide a comprehensive analysis of the expression pattern and distribution of NPNT in breast cancer tissue from 842 patients by immunohistochemical staining of tissue microarrays from a historic cohort. Several patterns of NPNT staining were observed. An association between granular cytoplasmic staining (in <10% of tumor cells) and poor prognosis was found. We suggest that granular cytoplasmic staining may represent NPNT-positive exosomes. We found that NPNT promotes adhesion and anchorage-independent growth via its integrin-binding and enhancer motifs and that enforced expression in breast tumor cells promotes their colonization of the lungs. We propose that NPNT may be a novel prognostic marker in a subgroup of breast cancer patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.