ArticleCell reports2018
A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
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Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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75citing papers in PubMed
11.9field-weighted citation impact, top 1% of its field
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75 citing papers in PubMed, 120 citations in OpenAlex.
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- Two Plasmodium vivax hypnozoite-expressed RNA-binding proteins inhibit liver stage replication.Nature communications · 2026Article
- Distribution of Plasmodium falciparum apical membrane antigen-1 cluster one loop haplotypes and their association with malaria symptoms in Bandiagara, Mali.BMC infectious diseases · 2026Article
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- A paradoxical population structure of var DBLα types in Africa.PLoS pathogens · 2025Article
- Genome-wide gene expression profiles throughout human malaria parasite liver stage development in humanized mice.Nature microbiology · 2025Article
- An inner membrane complex protein IMC1g inmBio · 2025Article
- Croquemort-scavenger receptor class B 2 (Journal of biosciences · 2025Article
- Heterochromatin dynamics during the initial stages of sexual development in Plasmodium falciparum.Scientific reports · 2024Article
- PfSPZ Vaccine induces focused humoral immune response in HIV positive and negative Tanzanian adults.EBioMedicine · 2024Article
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- TargetingVaccines · 2024Review
- Positive-unlabeled learning identifies vaccine candidate antigens in the malaria parasite Plasmodium falciparum.NPJ systems biology and applications · 2024Article
15 more citing papers are in PubMed but not listed here.
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Authors and funding
21 authors at 11 institutions in 4 countries.
Gigliola ZanghìSorbonne Universités, Université Pierre et Marie Curie-Paris 6, UMR S945, 75003 Paris, France; Institut National de la Santé et de la Recherche Médicale, U945, 75013 Paris, France; Unité Biologie des Interactions Hôte-Parasite, Département de Parasites et Insectes Vecteurs, Institut Pasteur, 75015 Paris, France; CNRS, ERL 9195, 75015 Paris, France; INSERM, Unit U1201, 75015 Paris, France; AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Service de Parasitologie Mycologie, Paris 75013, France.
Shruthi S VembarUnité Biologie des Interactions Hôte-Parasite, Département de Parasites et Insectes Vecteurs, Institut Pasteur, 75015 Paris, France; CNRS, ERL 9195, 75015 Paris, France; INSERM, Unit U1201, 75015 Paris, France.
Sebastian BaumgartenUnité Biologie des Interactions Hôte-Parasite, Département de Parasites et Insectes Vecteurs, Institut Pasteur, 75015 Paris, France; CNRS, ERL 9195, 75015 Paris, France; INSERM, Unit U1201, 75015 Paris, France.
Shuai DingUnité Biologie des Interactions Hôte-Parasite, Département de Parasites et Insectes Vecteurs, Institut Pasteur, 75015 Paris, France; CNRS, ERL 9195, 75015 Paris, France; INSERM, Unit U1201, 75015 Paris, France.
Julien GuizettiUnité Biologie des Interactions Hôte-Parasite, Département de Parasites et Insectes Vecteurs, Institut Pasteur, 75015 Paris, France; CNRS, ERL 9195, 75015 Paris, France; INSERM, Unit U1201, 75015 Paris, France.
Jessica M BryantUnité Biologie des Interactions Hôte-Parasite, Département de Parasites et Insectes Vecteurs, Institut Pasteur, 75015 Paris, France; CNRS, ERL 9195, 75015 Paris, France; INSERM, Unit U1201, 75015 Paris, France.
Denise MatteiUnité Biologie des Interactions Hôte-Parasite, Département de Parasites et Insectes Vecteurs, Institut Pasteur, 75015 Paris, France; CNRS, ERL 9195, 75015 Paris, France; INSERM, Unit U1201, 75015 Paris, France.
Anja T R JensenCentre for Medical Parasitology, Department of Immunology & Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), 2100 Copenhagen, Denmark.
Laurent RéniaLaboratory of Pathogen Immunobiology, Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A(∗)STAR), Biopolis, Singapore; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Yun Shan GohLaboratory of Pathogen Immunobiology, Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A(∗)STAR), Biopolis, Singapore.
Robert SauerweinDepartment of Medical Microbiology and Radboud Center for Infectious Diseases, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, the Netherlands.
Cornelus C HermsenDepartment of Medical Microbiology and Radboud Center for Infectious Diseases, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, the Netherlands.
Jean-François FranetichSorbonne Universités, Université Pierre et Marie Curie-Paris 6, UMR S945, 75003 Paris, France; Institut National de la Santé et de la Recherche Médicale, U945, 75013 Paris, France; AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Service de Parasitologie Mycologie, Paris 75013, France.
Mallaury BordessoullesSorbonne Universités, Université Pierre et Marie Curie-Paris 6, UMR S945, 75003 Paris, France; Institut National de la Santé et de la Recherche Médicale, U945, 75013 Paris, France; AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Service de Parasitologie Mycologie, Paris 75013, France.
Olivier SilvieSorbonne Universités, Université Pierre et Marie Curie-Paris 6, UMR S945, 75003 Paris, France; Institut National de la Santé et de la Recherche Médicale, U945, 75013 Paris, France; AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Service de Parasitologie Mycologie, Paris 75013, France.
Valérie SoulardSorbonne Universités, Université Pierre et Marie Curie-Paris 6, UMR S945, 75003 Paris, France; Institut National de la Santé et de la Recherche Médicale, U945, 75013 Paris, France; AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Service de Parasitologie Mycologie, Paris 75013, France.
Olivier ScattonService de Chirurgie Digestive, Hépato-Bilio-Pancréatique et Transplantation Hépatique, Hôpital Pitié-Salpêtrière, 75013 Paris, France.
Patty ChenUnité Biologie des Interactions Hôte-Parasite, Département de Parasites et Insectes Vecteurs, Institut Pasteur, 75015 Paris, France; CNRS, ERL 9195, 75015 Paris, France; INSERM, Unit U1201, 75015 Paris, France.
Salah MecheriUnité Biologie des Interactions Hôte-Parasite, Département de Parasites et Insectes Vecteurs, Institut Pasteur, 75015 Paris, France; CNRS, ERL 9195, 75015 Paris, France; INSERM, Unit U1201, 75015 Paris, France.
Dominique MazierSorbonne Universités, Université Pierre et Marie Curie-Paris 6, UMR S945, 75003 Paris, France; Institut National de la Santé et de la Recherche Médicale, U945, 75013 Paris, France; AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Service de Parasitologie Mycologie, Paris 75013, France. Electronic address: dominique.mazier@upmc.fr.
Artur ScherfUnité Biologie des Interactions Hôte-Parasite, Département de Parasites et Insectes Vecteurs, Institut Pasteur, 75015 Paris, France; CNRS, ERL 9195, 75015 Paris, France; INSERM, Unit U1201, 75015 Paris, France. Electronic address: artur.scherf@pasteur.fr.
Inserm · FRCentre National de la Recherche Scientifique · FRPitié-Salpêtrière Hospital · FRSorbonne Université · FRAssistance Publique – Hôpitaux de Paris · FRCopenhagen University Hospital · DKInstitut Pasteur · FRNational University of Singapore · SGRadboud University Medical Center · NLRadboud University Nijmegen · NLSingapore Immunology Network · SG
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heterochromatin plays a central role in the process of immune evasion, pathogenesis, and transmission of the malaria parasite Plasmodium falciparum during blood stage infection. Here, we use ChIP sequencing to demonstrate that sporozoites from mosquito salivary glands expand heterochromatin at subtelomeric regions to silence blood-stage-specific genes. Our data also revealed that heterochromatin enrichment is predictive of the transcription status of clonally variant genes members that mediate cytoadhesion in blood stage parasites. A specific member (here called NF54var
Indexed as
AnimalsHepatocytesProtozoan ProteinsSporozoiteserythrocyte membrane protein 1, Plasmodium falciparumProtozoan Proteinsepigenetichepatocyte infectionheterochromatinmalariaP. falciparumPfEMP1PfHP1sporozoitevar genes
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