ArticleCell reports2018
Cbx4 Sumoylates Prdm16 to Regulate Adipose Tissue Thermogenesis.
Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
- CBX4 stabilizes NEUROD1 through SUMO-ubiquitin crosstalk to delay β-cell senescence.Nature communications · 2026Article
- Transient SUMOylation inhibition in human pre-adipocytes stably imprints a transcriptional beiging fate.Nucleic acids research · 2026Article
- CBX4 Drives Gastric Cancer Progression by ActivatingOncology research · 2025Article
- Role and mechanism of the CBX4-HDAC5-CERS6 axis in disrupting sphingomyelin metabolism in acute myeloid leukemia.American journal of cancer research · 2025Article
- White-to-Beige and Back: Adipocyte Conversion and Transcriptional Reprogramming.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Directly targeting PRDM16 in thermogenic adipose tissue to treat obesity and its related metabolic diseases.Frontiers in endocrinology · 2024Review
- Tissue adaptation to metabolic stress: insights from SUMOylation.Frontiers in endocrinology · 2024Review
- Ubiquitination and Metabolic Disease.Advances in experimental medicine and biology · 2024Review
- CBX4 suppresses CD8Theranostics · 2024Article
- Cutting Edge: Polycomb Repressive Complex 1 Subunit Cbx4 Positively Regulates Effector Responses in CD8 T Cells.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Androgen Receptor is a Negative Regulator of PRDM16 in Beige Adipocyte.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Time-restricted eating alters the 24-hour profile of adipose tissue transcriptome in men with obesity.Obesity (Silver Spring, Md.) · 2023Article
- Article
- CBX4 contributes to HIV-1 latency by forming phase-separated nuclear bodies and SUMOylating EZH2.EMBO reports · 2022Article
- PRDM16 Regulating Adipocyte Transformation and Thermogenesis: A Promising Therapeutic Target for Obesity and Diabetes.Frontiers in pharmacology · 2022Review
- miR-515-5p inhibits the proliferation, migration and invasion of human breast cancer cells by targeting CBX4.Experimental and therapeutic medicine · 2021Article
- Sparcl1 promotes nonalcoholic steatohepatitis progression in mice through upregulation of CCL2.The Journal of clinical investigation · 2021Article
- SALL1 Modulates CBX4 Stability, Nuclear Bodies, and Regulation of Target Genes.Frontiers in cell and developmental biology · 2021Article
- Review
- CBX4 transcriptionally suppresses KLF6 via interaction with HDAC1 to exert oncogenic activities in clear cell renal cell carcinoma.EBioMedicine · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Transcriptional co-activator Prdm16 controls brown fat development and white fat browning, but how this thermogenic function is modulated post-translationally is poorly understood. Here, we report that Cbx4, a Polycomb group protein, is a SUMO E3 ligase for Prdm16 and that Cbx4-mediated sumoylation of Prdm16 is required for thermogenic gene expression. Cbx4 expression is enriched in brown fat and is induced in adipose tissue by acute cold exposure. Sumoylation of Prdm16 at lysine 917 by Cbx4 blocks its ubiquitination-mediated degradation, thereby augmenting its stability and thermogenic function. Moreover, this sumoylation event primes Prdm16 to be further stabilized by methyltransferase Ehmt1. Heterozygous Cbx4-knockout mice develop metabolic phenotypes resembling those of Prdm16-knockout mice. Furthermore, fat-specific Cbx4 knockdown and overexpression produce remarkable, opposite effects on white fat remodeling. Our results identify a modifying enzyme for Prdm16, and they demonstrate a central role of Cbx4 in the control of Prdm16 stability and white fat browning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.