ArticleBiophysical journal2018
Standard Loading Profile in Matrix Rigidity Sensing.
Article in Biophysical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Large and reversible myosin-dependent forces in rigidity sensing.Nature physics · 2019Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is important to learn features of locally applied forces by cells during matrix rigidity sensing, since the function of mechanosensing proteins would be affected by force magnitude, loading velocity, or even loading history. Here, we investigate a rigidity-sensing apparatus consisting of a contractile unit on matrices. Strikingly, our analysis indicates that the matrix rigidity is not only sensed with a fixed step size in displacement but also with a fixed apparent loading velocity. The fixed step size is shown to be correlated with the monomer size of actin filament. This work suggests that the loading profile during rigidity sensing is regulated by various aspects of the contractile unit, which then serves as the standard in sensing varied rigidity of the matrix.
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Registered trials
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