ArticleRevista do Instituto de Medicina Tropical de Sao Paulo2018
Visceral leishmaniasis in a Brazilian endemic area: an overview of occurrence, HIV coinfection and lethality.
Article in Revista do Instituto de Medicina Tropical de Sao Paulo, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 29 citations in OpenAlex.
- Assessment of asymptomaticFrontiers in medicine · 2025Article
- Human Visceral Leishmaniasis in Brazil in the Past 20 Years: An Epidemiologic Update.Revista da Sociedade Brasileira de Medicina Tropical · 2025Review
- Impact of COVID-19 on the incidence of visceral leishmaniasis in children and adolescents in the Northeast region, 2007-2022: time series study.Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil · 2025Article
- Factors associated with survival in patients with visceral leishmaniasis treated at a reference hospital in northern Minas Gerais - Brazil.Revista da Sociedade Brasileira de Medicina Tropical · 2024Article
- From Infection to Death: An Overview of the Pathogenesis of Visceral Leishmaniasis.Pathogens (Basel, Switzerland) · 2023Review
- High seroprevalence of Leishmania infantum is linked to immune activation in people with HIV: a two-stage cross-sectional study in Bahia, Brazil.Frontiers in microbiology · 2023Article
- Magnitude of visceral leishmaniasis and HIV coinfection and association with social determinants of health in the Northeast region of Brazil: a retrospective, spatiotemporal model (2010-2018).Parasitology research · 2022Article
- Diagnostic application of sensitive and specific phage-exposed epitopes for visceral leishmaniasis and human immunodeficiency virus coinfection.Parasitology · 2021Article
- Passive case detection for canine visceral leishmaniasis control in urban Brazil: Determinants of population uptake.PLoS neglected tropical diseases · 2021Article
- Nutritional status and vitamin A and zinc levels in patients with kala-azar in Piauí, Brazil.Revista da Sociedade Brasileira de Medicina Tropical · 2021Article
- Basic knowledge about visceral leishmaniasis before and after educational intervention among primary health care professionals in Midwestern Brazil.Revista do Instituto de Medicina Tropical de Sao Paulo · 2021Article
- Where, when, and how the diagnosis of human visceral leishmaniasis is defined: answers from the Brazilian control program.Memorias do Instituto Oswaldo Cruz · 2019Article
- Visceral leishmaniasis in Northeast Brazil: What is the impact of HIV on this protozoan infection?PloS one · 2019Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Brazilian municipality of Rondonópolis, Mato Grosso State, represents an important visceral leishmaniasis (VL) endemic area. This study described epidemiological and clinical aspects of the occurrence, VL/HIV coinfection and lethality related to VL in Rondonópolis. Data from autochthonous cases reported between 2011 and 2016 were obtained from official information systems. During this period, 81 autochthonous cases were reported, with decreasing incidence through 2016. Contrastingly, the lethality rate was 8.6% overall, but varied widely, reaching a peak (20%) in 2016. Almost 10% of patients had VL/HIVcoinfection. The occurrence of VL prevailed among men (56.8%), brown-skinned (49.4%), urban residents (92.6%), aged 0-4 years (33.3%). Housewives or retired (29.6%) were the most affected occupational groups. Lower age was the main difference among the total VL cases and those who were coinfected or died. Clinically, fever, weakness and splenomegaly were more frequent among all VL cases and VL/HIV coinfected individuals. Bacterial infections (p=0.001) and bleeding (p<0.001) were associated with death due to VL. Pentavalent antimonial and liposomal amphotericin B were the first choices for treatment among all VL cases (71.6%) and those who died (71.4%), respectively. VL/HIV patients were equally treated with both drugs. These findings may support control measures and demonstrate the need for further investigations.
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