ArticleArquivos brasileiros de cardiologia2018
Impact of a High-Intensity Training on Ventricular Function in Rats After Acute Myocardial Infarction.
Article in Arquivos brasileiros de cardiologia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 6 citations in OpenAlex.
- Effects of moderate- and high-intensity exercise on behavior and oxidative damage in male and female rats subjected to early life stress.Experimental brain research · 2026Article
- Strength training improves heart function, collagen and strength in rats with heart failure.The journal of physiological sciences : JPS · 2024Article
- Non-Pharmacological Treatment of Cardiovascular Disease | Importance of Physical Exercise.Arquivos brasileiros de cardiologia · 2019Article
- Endothelial Function and Physical Exercise.Arquivos brasileiros de cardiologia · 2018Article
- High-Intensity Interval Training for Early Post-Acute Myocardial Infarction - A Promising Approach for Rats, but what about Human Beings?Arquivos brasileiros de cardiologia · 2018Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPhysical exercise should be part of the treatment of post-acute myocardial infarction (AMI) patients.
objectiveTo evaluate the effects of two training prescription models (continuous x interval) and its impact on ventricular function in rats after AMI with normal ventricular function.
methodsForty Wistar rats were evaluated by echocardiography 21 days after the AMI. Those with LVEF = 50% (n = 29) were included in the study and randomized to control group (CG n = 10), continuous training group (CTG n = 9) or interval training group (ITG, n = 10). Then, a swimming test with control of lactate production was performed. Based on its result, the lactate threshold (LT) was established to define the training intensities. After six weeks, the animals were reassessed by echocardiography and lactate production. Outcome measures were end-diastolic diameter (EDD), end-systolic diameter (ESD), left ventricular ejection fraction (LVEF, %) lactate at rest, lactate without overload, and lactate with 12g and 13.5g of additional load. Group comparisons of quantitative variables of the study were performed by one-factor analysis of variance (ANOVA). The Newman-Keuls test was used for multiple comparisons of the groups. Within-group comparisons of dependent variables between the two training protocols were performed by Student's t-test. Normality of the variables was tested by the Shapiro-Wilks test. Values of p < 0.05 indicated statistical significance.
resultsEDD, ESD, and LVEF before and after the training period were similar in within-group comparisons. However, EDD was significantly different (p=0.008) in the CG. Significant differences were found for L12g (p=0.002) and L13.5g (p = 0.032) in the ITG, and for L12g (p = 0.014) in the CG. No differences were found in the echocardiographic parameters between the groups. Significant differences were found in lactate without overload (p = 0.016) and L12 (p = 0.031) in the second assessment compared with the first, and between the groups - ITG vs. CG (p = 0.019) and CTG vs. CG (p = 0.035).
conclusionBoth methods produced a training effect without altering ventricular function.
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