ArticlePloS one2018
Salivary microbial profiles in relation to age, periodontal, and systemic diseases.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.
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Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Age-Related Differences in Oral Microbiota Among Obese Patients with Periodontitis: A Systematic Review.Nutrients · 2026Pooled it
- Assessing periodontitis risk from specific dietary patterns: a systematic review and meta-analysis.Clinical oral investigations · 2025Pooled it
- Prevalence of red and orange microbial complexes in endodontic-periodontal lesions: a systematic review and meta-analysis.Clinical oral investigations · 2021Pooled it
- Salivary microbial profiles across periodontal severity stage according to the 2018 AAP/EFP classifications: a cross-sectional study.Frontiers in oral health · 2026Article
- Predicting age from binarized human oral microbial data combined with an ensemble of classifiers.mSystems · 2025Article
- The Effect of 6-Week Advanced Oral Care on Oral Microbiome and Mycobiome Composition in People With Dementia Living in Residential Aged Care.Clinical and experimental dental research · 2025Article
- ORMCKB: A Knowledge Database for Personalized Medicine in Deciphering the Oral Microbiome-Disease Axis.Interdisciplinary sciences, computational life sciences · 2025Article
- Characteristics of Subgingival Plaque Microbiome in Japanese Older Adults With Healthy Gingiva.Journal of clinical periodontology · 2025Article
- Distribution and Characteristics of Oral Pathogens According to Blood Glucose Levels in South Korean Health Examinees.International journal of molecular sciences · 2025Article
- Factors associated with tooth loss in patients with stages 3 and 4 periodontitis: a short-term retrospective evaluation of patients.3 Biotech · 2025Article
- Associations Between Oral Microbiota Pathogens and Elevated Depressive and Anxiety Symptoms in Men.Depression and anxiety · 2025Article
- Salivary microbiota and IgA responses are different in pre-diabetic individuals compared to normoglycemic controls.Frontiers in cellular and infection microbiology · 2025Article
- Salivary features of periodontitis and gingivitis in type 2 diabetes mellitus.Scientific reports · 2024Article
- The salivary metabolome of children and parental caregivers in a large-scale family environment study.npj metabolic health and disease · 2024Article
- Article
- Smoking and salivary microbiota: a cross-sectional analysis of an Italian alpine population.Scientific reports · 2023Article
- Comparison of immunoexpression of dendritic cells, mast cells and blood vessels in periodontal disease between adults and elderly.Clinical oral investigations · 2023Article
- Article
- Examining Myeloperoxidase (MPO) biomarker in the saliva of patients withJournal of medicine and life · 2023Article
- Impact of high altitude on composition and functional profiling of oral microbiome in Indian male population.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnalysis of saliva is emerging as a promising tool to diagnose and monitor diseases which makes determination of the salivary microbial profile in different scenarios essential.
objectiveTo evaluate the effects of age, periodontal disease, sex, smoking, and medical conditions on the salivary microbial profile.
designA randomly selected sample of 441 individuals was enrolled (51% women; mean age 48.5±16.8). Participants answered a health questionnaire and underwent an oral examination. Stimulated saliva was collected and the counts of 41 bacteria were determined by checkerboard DNA-DNA hybridization.
resultsElderly participants (> 64 years old) presented a significant increase in 24 out of 41 bacterial species compared to adults (≤ 64 years old). Eubacterium nodatum, Porphyromonas gingivalis, and Tannerella forsythia were significantly higher in participants with generalized bone loss compared to without. Males and non-smokers had higher bacteria counts in saliva. Individuals having mental disorders or muscle and joint diseases showed significantly altered microbial profiles whereas small or no differences were found for subjects with high blood pressure, heart disease, previous heart surgery, bowel disease, tumors, or diabetes.
conclusionAge, periodontal status, sex, smoking, and certain medical conditions namely, mental disorders and muscle and joint diseases, might affect the microbial profile in saliva.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.