Trial reportPloS one2018
Prospective association between handgrip strength and cardiac structure and function in UK adults.
Trial report in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Skeletal and cardiac muscle longitudinal associations in the Baltimore Longitudinal Study of Aging (BLSA).BMC medicine · 2026Article
- Association of Body Size and Muscle Grip Strength With Hypertension: A Cross-Sectional Study.Cureus · 2026Article
- Muscle Strength and Left Ventricular Systolic and Diastolic Dysfunction in Chronic Kidney Disease Men: A Pilot Study.Journal of clinical medicine · 2026Article
- The relationship between skeletal muscle mass and cardiac structure in elderly male inpatients.Frontiers in cardiovascular medicine · 2026Article
- Effect of sarcopenia on risk of atrial fibrillation: a systematic review and meta-analysis of observational studies.Frontiers in cardiovascular medicine · 2026Review
- Biological Sex and the Association Between Grip Strength and Cardiovascular Disease: a Scoping Review.Canadian geriatrics journal : CGJ · 2025Review
- Analysis of Grip Strength Thresholds for Stroke Management and Prevention in South Korean Older Adults.Healthcare (Basel, Switzerland) · 2025Article
- Study research protocol for Phenome India-CSIR Health Cohort Knowledgebase: A prospective multi-modal follow-up study on a nationwide employee cohort.Biology methods & protocols · 2025Article
- Association between baseline levels of muscular strength and risk of stroke in later life: The Cooper Center Longitudinal Study.Journal of sport and health science · 2024Article
- Handgrip strength, and erectile dysfunction among men with metabolic syndrome attending an institutional primary care clinic in Malaysia: A cross-sectional study.Journal of family medicine and primary care · 2024Article
- Reduced thoracic skeletal muscle size is associated with adverse outcomes in diabetes patients with heart failure and reduced ejection fraction: quantitative analysis of sarcopenia by using cardiac MRI.Cardiovascular diabetology · 2024Article
- Association of Handgrip Strength and Cardiovascular Disease Risk Among Middle-Aged Postmenopausal Women: An Analysis of the Korea National Health and Nutrition Examination Survey 2014-2019.Vascular health and risk management · 2024Article
- Causal influence of muscle weakness on cardiometabolic diseases and osteoporosis.Scientific reports · 2023Article
- Development and validation of dynamic nomogram of frailty risk for older patients hospitalized with heart failure.International journal of nursing sciences · 2023Article
- Field-Based Estimates of Muscle Quality Index Determine Timed-Up-and-Go Test Performance in Obese Older Women.Clinical interventions in aging · 2023Article
- Current Approach to the Diagnosis of Sarcopenia in Heart Failure: A Narrative Review on the Role of Clinical and Imaging Assessments.Circulation. Heart failure · 2022Review
- Article
- Determination of hand grip strength and its correlates during pregnancy: a cross-sectional study.BMC pregnancy and childbirth · 2021Article
- Dynamic handgrip exercise for the evaluation of mitral valve regurgitation: an echocardiographic study to identify exertion induced severe mitral regurgitation.The international journal of cardiovascular imaging · 2021Article
- Physical frailty and long-term mortality in older people with chronic heart failure with preserved and reduced ejection fraction: a retrospective longitudinal study.BMC geriatrics · 2021Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
backgroundHandgrip strength, a measure of muscular fitness, is associated with cardiovascular (CV) events and CV mortality but its association with cardiac structure and function is unknown. The goal of this study was to determine if handgrip strength is associated with changes in cardiac structure and function in UK adults. METHODS AND
resultsLeft ventricular (LV) ejection fraction (EF), end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), mass (M), and mass-to-volume ratio (MVR) were measured in a sample of 4,654 participants of the UK Biobank Study 6.3 ± 1 years after baseline using cardiovascular magnetic resonance (CMR). Handgrip strength was measured at baseline and at the imaging follow-up examination. We determined the association between handgrip strength at baseline as well as its change over time and each of the cardiac outcome parameters. After adjustment, higher level of handgrip strength at baseline was associated with higher LVEDV (difference per SD increase in handgrip strength: 1.3ml, 95% CI 0.1-2.4; p = 0.034), higher LVSV (1.0ml, 0.3-1.8; p = 0.006), lower LVM (-1.0g, -1.8 --0.3; p = 0.007), and lower LVMVR (-0.013g/ml, -0.018 --0.007; p<0.001). The association between handgrip strength and LVEDV and LVSV was strongest among younger individuals, while the association with LVM and LVMVR was strongest among older individuals.
conclusionsBetter handgrip strength was associated with cardiac structure and function in a pattern indicative of less cardiac hypertrophy and remodeling. These characteristics are known to be associated with a lower risk of cardiovascular events.
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