ArticlePLoS biology2018
Modifying and reacting to the environmental pH can drive bacterial interactions.
Article in PLoS biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 187 papers.
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Who cites it
187 citing papers in PubMed.
- It takes a village: how plant-associated bacterial communities socialise to shape plant growth and health.Essays in biochemistry · 2026Review
- Production optimization scale-up and application of a multifunctional enzyme cocktail for eco-friendly pulp biobleaching.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Systematic profiling of growth interactions in human gut microbiome species.Nature communications · 2026Article
- Beyond the Standard Antibiogram: Unveiling the Roles of pH and Salinity in Modulating Gentamicin Efficacy Against Escherichia coli in Urinary Tract Infections.MicrobiologyOpen · 2026Article
- Metabolic set theory: a generalized model of microbial interactions.NPJ systems biology and applications · 2026Article
- Heavy Metal-Driven Oral Dysbiosis: Salivary Toxicometallomics at the Host-Microbiome Interface Across Pathologies.Life (Basel, Switzerland) · 2026Review
- Article
- The network structure of cross-feeding impacts microbial community diversity under growth-inhibiting stresses.Nature communications · 2026Article
- Minimizing co-growth as a broad predictor of community robustness.bioRxiv : the preprint server for biology · 2026Article
- Liquid digestate treatment potential of five green microalgae in non-axenic cultures.Scientific reports · 2026Article
- Environmental cues shape extracellular vesicles biogenesis and function in Streptococcus pneumoniae.BMC microbiology · 2026Article
- The impact of urine pH on lithogenic risk profile in children with urolithiasis.Pediatric nephrology (Berlin, Germany) · 2026Article
- Acidifying bacteria inhibit pathogenic bacteria more strongly with increasing glucose.The ISME journal · 2026Article
- Metabolic blueprints of monocultures enable prediction and design of synthetic microbial consortia.bioRxiv : the preprint server for biology · 2026Article
- Spatial structure: shaping the ecology and evolution of microbial communities.FEMS microbiology reviews · 2026Review
- Light force-powered cellular medical micromachines.Frontiers in bioengineering and biotechnology · 2026Review
- A microbiologist's field guide to community ecology.ISME communications · 2026Review
- Navigating the duality of Akkermansia muciniphila.Nature microbiology · 2026Review
- Article
- Antibiotics and priority effects on colonizing resistant Escherichia coli strain assemblages in a community setting.PloS one · 2026Article
127 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Microbes usually exist in communities consisting of myriad different but interacting species. These interactions are typically mediated through environmental modifications; microbes change the environment by taking up resources and excreting metabolites, which affects the growth of both themselves and also other microbes. We show here that the way microbes modify their environment and react to it sets the interactions within single-species populations and also between different species. A very common environmental modification is a change of the environmental pH. We find experimentally that these pH changes create feedback loops that can determine the fate of bacterial populations; they can either facilitate or inhibit growth, and in extreme cases will cause extinction of the bacterial population. Understanding how single species change the pH and react to these changes allowed us to estimate their pairwise interaction outcomes. Those interactions lead to a set of generic interaction motifs-bistability, successive growth, extended suicide, and stabilization-that may be independent of which environmental parameter is modified and thus may reoccur in different microbial systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.