Evidence map›Paper›PMID 29538284›Full record

ArticleMolecules (Basel, Switzerland)2018

Identification of the NADPH Oxidase 4 Inhibiting Principle of Lycopus europaeus.

Silvia Revoltella, Giorgia Baraldo, Birgit Waltenberger, Stefan Schwaiger, Philipp Kofler, Julia Moesslacher, Astrid Huber-Seidel, Konrad Pagitz, Roland Kohl, Pidder Jansen-Duerr and 1 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. NADPH Oxidases in Aortic Aneurysms.Antioxidants (Basel, Switzerland) · 2022
    Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Silvia RevoltellaInstitute of Pharmacy/Pharmacognosy and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, 6020 Innsbruck, Austria. silvia.revoltella@uibk.ac.at.
Giorgia BaraldoInstitute for Biomedical Aging Research and CMBI, University of Innsbruck, 6020 Innsbruck, Austria. giorgia.baraldo@uibk.ac.at.
Birgit WaltenbergerInstitute of Pharmacy/Pharmacognosy and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, 6020 Innsbruck, Austria. birgit.waltenberger@uibk.ac.at.
Stefan SchwaigerInstitute of Pharmacy/Pharmacognosy and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, 6020 Innsbruck, Austria. stefan.schwaiger@uibk.ac.at.ORCID 0000-0002-3731-7349
Philipp KoflerInstitute for Biomedical Aging Research and CMBI, University of Innsbruck, 6020 Innsbruck, Austria. kofler.philipp@gmail.com.
Julia MoesslacherCura Marketing GmbH, 6020 Innsbruck, Austria. julia.moesslacher@cura.co.at.
Astrid Huber-SeidelCura Marketing GmbH, 6020 Innsbruck, Austria. astrid.huber-seidel@cura.co.at.
Konrad PagitzInstitute of Botany, University of Innsbruck, 6020 Innsbruck, Austria. konrad.pagitz@uibk.ac.at.
Roland KohlCura Marketing GmbH, 6020 Innsbruck, Austria. roland.kohl@cura.co.at.
Pidder Jansen-DuerrInstitute for Biomedical Aging Research and CMBI, University of Innsbruck, 6020 Innsbruck, Austria. pidder.jansen-duerr@uibk.ac.at.
Hermann StuppnerInstitute of Pharmacy/Pharmacognosy and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, 6020 Innsbruck, Austria. hermann.stuppner@uibk.ac.at.
Universität Innsbruck · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

NADPH oxidase 4 (Nox4) has recently been implicated as driving force in cellular senescence. Thus, there is growing interest to develop Nox4 inhibitors, which might be valuable agents for cosmeceutical applications. Alpine plants represent a valuable source for the identification of novel bioactive natural products with anti-ageing effects, especially substances that protect plants against UV radiation, which is also known to contribute to the ageing of human skin. Therefore, the aim of this study was to identify novel Nox4 inhibitors from alpine plants. Within an initial screening of extracts of alpine plants on their ability to inhibit Nox4 activity in HEK cells, the methanolic extract of the subaerial parts of

Indexed as

Cell LineCell SurvivalCinnamatesDepsidesDose-Response Relationship, DrugEnzyme InhibitorsGene Expression RegulationHEK293 CellsHumansLycopusMethanolNADPH Oxidase 2NADPH Oxidase 4Plant Components, AerialPlant ExtractsReactive Oxygen SpeciesCinnamatesCYBB protein, humanDepsidesEnzyme InhibitorsMethanolNADPH Oxidase 2NADPH Oxidase 4NOX4 protein, humanPlant ExtractsReactive Oxygen SpeciesRosmarinic Acidanti-ageingLycopus europaeusNADPH oxidase 4ROSrosmarinic acid

Identifiers

PMID29538284
PMCPMC6017630
OpenAlexW2792944363

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.