Evidence map›Paper›PMID 29538044›Full record

ReviewCurrent opinion in pediatrics2018

Mechanisms for intestinal regeneration.

Genia Dubrovsky, James C Y Dunn

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Submucosal Hydrogel for Spring-Mediated Intestinal Lengthening.Journal of biomedical materials research. Part A · 2025
    Article
  2. Review
  3. Review
  4. Effects of DietaryAnimals : an open access journal from MDPI · 2024
    Article
  5. Article
  6. Stem cells and lung regeneration.American journal of physiology. Cell physiology · 2020
    Review
  7. Review
  8. Article
  9. Circadian Regulation in Tissue Regeneration.International journal of molecular sciences · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Genia DubrovskyDepartment of Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles.
James C Y DunnDivision of Pediatric Surgery, Department of Surgery, Stanford University, Stanford, California, USA.
Stanford University · USUniversity of California, Los Angeles · US

Funding

Intestinal Stem Cell Consortium Coordinating CenterU01DK085532 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI NILAND, JOYCE CAROL · 2009 to 2018
$6.5M
Limited Competition for the Continuation of the Intestinal Stem Cell Consortium Coordinating CenterU24DK085532 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI NILAND, JOYCE CAROL · 2019 to 2023
$2.3M
Spring Mediated EnterogenesisR01DK130972 · NIDDK · STANFORD UNIVERSITY · PI James C Dunn · 2021 to 2026
$1.8M
Intestinal Tissue EngineeringR01DK083319 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUNN, JAMES C · 2010 to 2012
$998k
NIDDK NIH HHS R01 DK083319NIDDK NIH HHS R01 DK130972NIDDK NIH HHS U01 DK085532NIDDK NIH HHS U24 DK085532
6 · The paper itself

Abstract

purpose of reviewThe purpose of this review is to briefly summarize the notable structures and pathways in intestinal epithelial growth before presenting the current main areas of active research in intestinal regeneration. As a rapidly advancing field, a number of breakthroughs have recently been made related to the culture of intestinal stem cells (ISCs) and to the engineering of intestinal tissue. RECENT

findingsISCs can be derived from fibroblasts and can be cultured in hydrogels under xenogeneic-free conditions. Intestinal organoids can be cultured with neural crest cells to form small intestinal tissues with neuromuscular networks. Endoluminal devices can be placed inside the native intestine to exert mechanical force to induce novel tissue growth. SUMMARY: A number of recent advances in the field of intestinal regeneration are encouraging and suggest that novel therapies for a wide range of intestinal disorders may be developed in the near future. There are still a number of obstacles before such stem cell therapies can be safely used in humans.

Indexed as

Cell Culture TechniquesCells, CulturedGuided Tissue RegenerationHumansIntestinal DiseasesIntestinal MucosaIntestinesOrganoidsRegenerationStem CellsStem Cell TransplantationTissue Engineering

Identifiers

PMID29538044
PMCPMC10308558
OpenAlexW2793463445

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.