Evidence map›Paper›PMID 29537934›Full record

ReviewAdipocyte2018

The role of polyunsaturated fatty acids (n-3 PUFAs) on the pancreatic β-cells and insulin action.

Habtamu Wondifraw Baynes, Seifu Mideksa, Sintayehu Ambachew

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Adipocyte, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Habtamu Wondifraw Baynesb Department of Clinical Chemistry , School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar , Northwest Ethiopia.
Seifu Mideksaa Clinical Chemistry laboratory, Ayder Comprehensive Specialized Hospital , Mekelle , Northern , Ethiopia.
Sintayehu Ambachewb Department of Clinical Chemistry , School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar , Northwest Ethiopia.
University of Gondar · ETMekelle University · ET

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polyunsaturated Fatty acids have multiple effects in peripheral tissues and pancreatic beta cell function. The n-3 Polyunsaturated Fatty acids prevent and reverse high-fat-diet induced adipose tissue inflammation and insulin resistance. Insulin secretion is stimulated by glucose, amino acids, and glucagon- like peptide-1 in tissue containing high levels of n-3 Polyunsaturated Fatty acids than lower level of n-3 Polyunsaturated Fatty acids. Also, n-3 Polyunsaturated Fatty acids led to decreased production of prostaglandin, which in turn contributed to the elevation of insulin secretion. N-3 polyunsaturated fatty acids prevent cytokine-induced cell death in pancreatic islets. Supplementation of n-3 Polyunsaturated Fatty acids for human subjects prevent beta cell destruction and insulin resistance. It also enhances insulin secretion, reduction in lipid profiles and glucose concentration particularly in type II diabetes patients. Therefore there should be a focus on the treatment mechanism of insulin related obesity and diabetes by n-3 polyunsaturated fatty acids.

Indexed as

AnimalsCell DeathCytokinesFatty Acids, Omega-3HumansInsulinInsulin-Secreting CellsCytokinesFatty Acids, Omega-3Insulininsulin resistanceinsulin secretionn-3 PUFAspancreatic β-cells

Identifiers

PMID29537934
PMCPMC6152539
OpenAlexW2790760819

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.