ReviewJournal of neurophysiology2018
Sherlock Holmes and the curious case of the human locomotor central pattern generator.
Review in Journal of neurophysiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 70 citations in OpenAlex.
- Feedback-based perturbation balance training during stationary cycling improves reactive and proactive balance among older adults: a single-blinded randomised controlled trial.Age and ageing · 2025Trial
- Age-related changes in mobility assessments correlate with repetitive goal-directed arm-movement performance.BMC geriatrics · 2023Trial
- Robotic Rehabilitation in Spinal Cord Injury: A Pilot Study on End-Effectors and Neurophysiological Outcomes.Annals of biomedical engineering · 2021Trial
- Development and piloting of a perturbation stationary bicycle robotic system that provides unexpected lateral perturbations during bicycling (the PerStBiRo system).BMC geriatrics · 2021Trial
- Corticospinal excitability is higher during synchronous vs asynchronous arm cycling.European journal of applied physiology · 2026Article
- Pushing the Limits of Interlimb Connectivity: Neuromodulation and Beyond.Biomedicines · 2025Review
- Modulating arm swing via haptic cueing alters interlimb neural coupling in older adults.Frontiers in physiology · 2025Article
- Gait Training of Healthy Older Adults in a Sitting Position using the Wearable Robot to Assist Arm-swing Rhythm, WALK-MATE ROBOT.Scientific reports · 2024Article
- Positional Obstructive Sleep Apnea and Periodic Limb Movements During Sleep: A Large Multicenter Study.Clinical and experimental otorhinolaryngology · 2024Article
- Biomechanical Assessment Methods Used in Chronic Stroke: A Scoping Review of Non-Linear Approaches.Sensors (Basel, Switzerland) · 2024Article
- Roles for cerebellum and subsumption architecture in central pattern generation.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Review
- Neuromuscular Anatomy and Motor Patterns at the Base of Calling Behaviour in the Female Spongy MothInsects · 2024Article
- Sensorimotor adaptation of locomotor synergies to gravitational constraint.NPJ microgravity · 2024Article
- Development of an Elliptical Perturbation System that provides unexpected perturbations during elliptical walking (the EPES system).Journal of neuroengineering and rehabilitation · 2023Article
- Do Patients with Parkinson's Disease Benefit from Dynamic Body Weight Support? A Pilot Study on the Emerging Role of Rysen.Biomedicines · 2023Article
- Gait Recovery in Spinal Cord Injury: A Systematic Review with Metanalysis Involving New Rehabilitative Technologies.Brain sciences · 2023Review
- Synaptogenic gene therapy with FGF22 improves circuit plasticity and functional recovery following spinal cord injury.EMBO molecular medicine · 2023Article
- Variation in the rate of recovery in motor function between the upper and lower limbs in patients with stroke: some proposed hypotheses and their implications for research and practice.Frontiers in neurology · 2023Article
- Targeting CNS Neural Mechanisms of Gait in Stroke Neurorehabilitation.Brain sciences · 2022Article
- Lower Limb Kinematic Coordination during the Running Motion of Stroke Patient: A Single Case Study.Journal of functional morphology and kinesiology · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence first described in reduced animal models over 100 years ago led to deductions about the control of locomotion through spinal locomotor central pattern-generating (CPG) networks. These discoveries in nature were contemporaneous with another form of deductive reasoning found in popular culture, that of Arthur Conan Doyle's detective, Sherlock Holmes. Because the invasive methods used in reduced nonhuman animal preparations are not amenable to study in humans, we are left instead with deducing from other measures and observations. Using the deductive reasoning approach of Sherlock Holmes as a metaphor for framing research into human CPGs, we speculate and weigh the evidence that should be observable in humans based on knowledge from other species. This review summarizes indirect inference to assess "observable evidence" of pattern-generating activity that leads to the logical deduction of CPG contributions to arm and leg activity during locomotion in humans. The question of where a CPG may be housed in the human nervous system remains incompletely resolved at this time. Ongoing understanding, elaboration, and application of functioning locomotor CPGs in humans is important for gait rehabilitation strategies in those with neurological injuries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.