ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2018
Effects of exercise in a cold environment on transcriptional control of PGC-1α.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Exercise and cold exposure as dual physiological stressors in MASLD: AMPK-mediated metabolic adaptation and interorgan crosstalk.Frontiers in physiology · 2026Review
- Traditional Health Practices May Promote Nrf2 Activation Similar to Exercise.International journal of molecular sciences · 2025Review
- Bone Modelling and Remodelling in Cold Environment.Biomolecules · 2025Review
- Performance nutrition for cold-weather military operations.International journal of circumpolar health · 2023Article
- The Influence of Winter Swimming on Oxidative Stress Indicators in the Blood of Healthy Males.Metabolites · 2023Article
- Melatonin Potentiates Exercise-Induced Increases in Skeletal Muscle PGC-1Frontiers in physiology · 2022Article
- Regulation of Adipose Thermogenesis and its Critical Role in Glucose and Lipid Metabolism.International journal of biological sciences · 2022Review
- The Acute Effects of Exercise and Temperature on Regional mtDNA.International journal of environmental research and public health · 2021Article
- Effect of local cold application during exercise on gene expression related to mitochondrial homeostasis.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2021Article
- Adaptations to Post-exercise Cold Water Immersion: Friend, Foe, or Futile?Frontiers in sports and active living · 2021Review
- Exercise- and Cold-Induced HumanInternational journal of environmental research and public health · 2020Article
- Review
- Effects of 7°C environmental temperature acclimation during a 3-week training period.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- FOXO1 inhibition prevents renal ischemia-reperfusion injury via cAMP-response element binding protein/PPAR-γ coactivator-1α-mediated mitochondrial biogenesis.British journal of pharmacology · 2020Article
- Effects of exercise in a cold environment on gene expression for mitochondrial biogenesis and mitophagy.Cryobiology · 2019Article
- Skeletal muscle cold shock and heat shock protein mRNA response to aerobic exercise in different environmental temperatures.Temperature (Austin, Tex.) · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Peroxisome proliferator-activated receptor-α coactivator-1α (PGC-1α) mRNA is increased with both exercise and exposure to cold temperature. However, transcriptional control has yet to be examined during exercise in the cold. Additionally, the need for environmental cold exposure after exercise may not be a practical recovery modality. The purpose of this study was to determine mitochondrial-related gene expression and transcriptional control of PGC-1α following exercise in a cold compared with room temperature environment. Eleven recreationally trained males completed two 1-h cycling bouts in a cold (7°C) or room temperature (20°C) environment, followed by 3 h of supine recovery in standard room conditions. Muscle biopsies were taken from the vastus lateralis preexercise, postexercise, and after a 3-h recovery. Gene expression and transcription factor binding to the PGC-1α promoter were analyzed. PGC-1α mRNA increased from preexercise to 3 h of recovery, but there was no difference between trials. Estrogen-related receptor-α (ERRα), myocyte enhancer factor-2 (MEF2A), and nuclear respiratory factor-1 (NRF-1) mRNA were lower in cold than at room temperature. Forkhead box class-O (FOXO1) and cAMP response element-binding protein (CREB) binding to the PGC-1α promoter were increased postexercise and at 3 h of recovery. MEF2A binding increased postexercise, and activating transcription factor 2 (ATF2) binding increased at 3 h of recovery. These data indicate no difference in PGC-1α mRNA or transcriptional control after exercise in cold versus room temperature and 3 h of recovery. However, the observed reductions in the mRNA of select transcription factors downstream of PGC-1α indicate a potential influence of exercise in the cold on the transcriptional response related to mitochondrial biogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.