ArticleACS applied materials & interfaces2018
Label-Free Detection of DNA Mutations by Nanopore Analysis.
Article in ACS applied materials & interfaces, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Background-Free Nanopore Decoding of microRNA Expression Patterns Using Circular Diagnostic DNA.Analytical chemistry · 2026Article
- A Comparative Review of Methods for Detecting Epidermal Growth Factor Receptor Mutations in Cell-free DNA from Lung Cancer Patients.Current molecular medicine · 2026Review
- Regulation of Protein Transport in Functionalized PET Nanopores.The journal of physical chemistry. B · 2025Article
- Pioneering Role of Nanopore Single-Molecule Sensing in Environmental and Food Surveillance.Biosensors · 2025Review
- Nanopore-based detection of periodontitis biomarker miR31 in saliva samples.Electrophoresis · 2024Article
- Article
- Probe-assisted detection of FeBiosensors & bioelectronics · 2024Article
- Nanoparticle-assisted detection of nucleic acids in a polymeric nanopore with a large pore size.Biosensors & bioelectronics · 2022Article
- Recent advances in biological nanopores for nanopore sequencing, sensing and comparison of functional variations in MspA mutants.RSC advances · 2021Review
- Attachment of Single-Stranded DNA to Certain SERS-Active Gold and Silver Substrates: Selected Practical Tips.Molecules (Basel, Switzerland) · 2021Article
- Chemically functionalized conical PET nanopore for protein detection at the single-molecule level.Biosensors & bioelectronics · 2020Article
- Single-molecule Study on the Interactions between Cyclic Nonribosomal Peptides and Protein Nanopore.ACS applied bio materials · 2020Article
- Single-molecule nanopore sensing of actin dynamics and drug binding.Chemical science · 2019Article
- Salt-Mediated Nanopore Detection of ADAM-17.ACS applied bio materials · 2019Article
- Nanopore label-free detection of single-nucleotide deletion in Baxα/BaxΔ2.Electrophoresis · 2018Article
- Nanopore Detection of Cancer Biomarkers: A Challenge to Science.Technology in cancer research & treatmentArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Cancers are caused by mutations to genes that regulate cell normal functions. The capability to rapid and reliable detection of specific target gene variations can facilitate early disease detection and diagnosis and also enables personalized treatment of cancer. Most of the currently available methods for DNA mutation detection are time-consuming and/or require the use of labels or sophisticated instruments. In this work, we reported a label-free enzymatic reaction-based nanopore sensing strategy to detect DNA mutations, including base substitution, deletion, and insertion. The method was rapid and highly sensitive with a detection limit of 4.8 nM in a 10 min electrical recording. Furthermore, the nanopore assay could differentiate among perfect match, one mismatch, and two mismatches. In addition, simulated serum samples were successfully analyzed. Our developed nanopore-based DNA mutation detection strategy should find useful application in genetic diagnosis.
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