Evidence map›Paper›PMID 29537820›Full record

ArticleACS nano2018

Kinetic Analysis of Nanostructures Formed by Enzyme-Instructed Intracellular Assemblies against Cancer Cells.

Jie Li, Domenico Bullara, Xuewen Du, Hongjian He, Stavroula Sofou, Ioannis G Kevrekidis, Irving R Epstein, Bing Xu

Abstract read
In one paragraph

Article in ACS nano, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 44 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Enzymatic Noncovalent Synthesis.Chemical reviews · 2020
    Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Assemblies of Peptides in a Complex Environment and their Applications.Angewandte Chemie (International ed. in English) · 2019
    Review
  14. Cell-Compatible Nanoprobes for Imaging Intracellular Phosphatase Activities.Chembiochem : a European journal of chemical biology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jie LiDepartment of Chemistry , Brandeis University , 415 South Street , Waltham , Massachusetts 02454 , United States.
Domenico BullaraDepartment of Chemistry , Brandeis University , 415 South Street , Waltham , Massachusetts 02454 , United States.
Xuewen DuDepartment of Chemistry , Brandeis University , 415 South Street , Waltham , Massachusetts 02454 , United States.
Hongjian HeDepartment of Chemistry , Brandeis University , 415 South Street , Waltham , Massachusetts 02454 , United States.
Stavroula SofouDepartment of Chemical and Biomolecular Engineering , Johns Hopkins University , Baltimore , Maryland 21218 , United States.
Ioannis G KevrekidisDepartment of Chemical and Biomolecular Engineering , Johns Hopkins University , Baltimore , Maryland 21218 , United States.
Irving R EpsteinDepartment of Chemistry , Brandeis University , 415 South Street , Waltham , Massachusetts 02454 , United States.ORCID 0000-0003-3180-4055
Bing XuDepartment of Chemistry , Brandeis University , 415 South Street , Waltham , Massachusetts 02454 , United States.ORCID 0000-0002-4639-387X
Brandeis University · USJohns Hopkins University · US

Funding

Subcellular Enzyme-instructed self-assembly for molecular anticancer nanomedicinesR01CA142746 · NCI · BRANDEIS UNIVERSITY · PI Bing Xu · 2010 to 2026
$6.4M
NCI NIH HHS R01 CA142746
6 · The paper itself

Abstract

Recent studies have demonstrated that enzyme-instructed self-assembly (EISA) in extra- or intracellular environments can serve as a multistep process for controlling cell fate. There is little knowledge, however, about the kinetics of EISA in the complex environments in or around cells. Here, we design and synthesize three dipeptidic precursors (ld-1-SO

Indexed as

Antineoplastic AgentsCarboxylic Ester HydrolasesCell ProliferationCell SurvivalDipeptidesDrug Screening Assays, AntitumorFemaleHumansHydrolysisKineticsNanostructuresOvarian NeoplasmsAntineoplastic AgentsCarboxylic Ester HydrolasesDipeptidesanticancerenzymenanostructureself-assemblystereochemistry

Identifiers

PMID29537820
PMCPMC5916050
OpenAlexW2789257593

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.