ArticleJournal of diabetes investigation2018
Delay in glucose peak time during the oral glucose tolerance test as an indicator of insulin resistance and insulin secretion in type 2 diabetes patients.
Article in Journal of diabetes investigation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 54 citations in OpenAlex.
- The impact of an acute high polyphenol, high fiber meal with and without aerobic exercise on metabolism in middle-aged and older adults: A pilot study.Physiological reports · 2025Trial
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- Comparison of the Effects of a Bean-Based and a White Rice-Based Breakfast Diet on Postprandial Glucose and Insulin Levels in Chinese Patients with Type 2 Diabetes.Medical science monitor : international medical journal of experimental and clinical research · 2021Trial
- Chitosan oligosaccharide (GO2KA1) improves postprandial glycemic response in subjects with impaired glucose tolerance and impaired fasting glucose and in healthy subjects: a crossover, randomized controlled trial.Nutrition & diabetes · 2019Trial
- Glucose curve morphology and peak time as biomarkers of metabolic health.American journal of physiology. Endocrinology and metabolism · 2026Article
- No effects of respiratory muscle endurance exercises on postprandial glucose excursions.Frontiers in sports and active living · 2026Article
- The rare glucose response curve during oral glucose tolerance tests in pregnant Chinese women and its association with preterm birth.Archives of medical science : AMS · 2026Article
- Hypogonadotropic Hypogonadism in a Central Obesity Patient with 46, XY, t(1; 10)(q42; q24).JBRA assisted reproduction · 2025Article
- Metabolic reprogramming in Fanconi anemia: Evidence of compromised glucose oxidation, enhanced ketogenesis, and metabolic inflexibility.Science advances · 2025Article
- Computational modeling enables individual assessment of postprandial glucose and insulin responses after bariatric surgery.Communications medicine · 2025Article
- Association between early-stage diabetic nephropathy and the delayed monophasic glucose peak during oral glucose tolerance test in type 2 diabetes mellitus.Journal of diabetes investigation · 2025Observational
- High Blood Glucose After Starch Loading in Young Women With Small Increase in Salivary Amylase: Another Crucial Role of Postprandial Salivary Amylase.Journal of clinical medicine research · 2024Article
- Article
- Validation of Doi's weighted average glucose as a measure of post-load glucose excursion for clinical use.Biomolecules & biomedicine · 2023Article
- The Glycemic Curve during the Oral Glucose Tolerance Test: Is It Only Indicative of Glycoregulation?Biomedicines · 2023Article
- Olive Leaf Tea Impact on Postprandial Glycemia: A Randomized Cross-Over Trial.Foods (Basel, Switzerland) · 2023Article
- Selenoprotein F Knockout Caused Glucose Metabolism Disorder in Young Mice by Disrupting Redox Homeostasis.Antioxidants (Basel, Switzerland) · 2022Article
- Modulation of 1,2-Dicarbonyl Compounds in Postprandial Responses Mediated by Food Bioactive Components and Mediterranean Diet.Antioxidants (Basel, Switzerland) · 2022Review
- Oral Glucose Tolerance Test in Patients with Cystic Fibrosis Compared to the Overweight and Obese: A Different Approach in Understanding the Results.Children (Basel, Switzerland) · 2022Article
- Changes in OGTT-derived biomarkers in response to lifestyle intervention among Latino adolescents with obesity.Pediatric obesity · 2022Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
AIMS/
introductionPrevious studies have shown that glucose peak time during the oral glucose tolerance test varies in type 2 diabetes patients; however, characteristics of this heterogeneity remain unclear. This research aimed to investigate the characteristics of delayed glucose peak time in type 2 diabetes. MATERIALS AND
methodsA total of 178 participants who underwent the oral glucose tolerance test were divided into five groups according to glucose peak time.
resultsA total of 25 participants with normal glucose tolerance had a glucose peak at 30 min. Among participants with type 2 diabetes, 28 had a glucose peak at 60 min, 48 at 90 min, 45 at 120 min and 32 at 150 min. With the glucose peak time delayed, glycated hemoglobin, area under the glucose curve and homeostatic model assessment of insulin resistance increased gradually (P = 0.038, P < 0.0001, P < 0.0001, respectively), and oral glucose insulin sensitivity, homeostatic model assessment of β-cell function, insulinogenic index, modified β-cell function index and disposition indices decreased (P < 0.0001 for all). On multinominal logistic regression, insulinogenic index (odds ratio 0.73, 95% confidence interval 0.57-0.93, P = 0.01), modified β-cell function index (odds ratio 0.67, 95% confidence interval 0.47-0.94, P = 0.023) and oral glucose insulin sensitivity (odds ratio 0.91, 95% confidence interval 0.87-0.96, P < 0.0001) were independently correlated with delayed glucose peak time.
conclusionsDelay in glucose peak time indicated an increase in blood glucose and a decrease in insulin sensitivity and secretion. Furthermore, insulinogenic index, modified β-cell function index and oral glucose insulin sensitivity contributed to delayed glucose peak time.
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