Evidence map›Paper›PMID 29537368›Full record

ArticleeLife2018

Gene network analysis identifies a central post-transcriptional regulator of cellular stress survival.

Matthew Tien, Aretha Fiebig, Sean Crosson

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Matthew TienDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, United States.ORCID http://orcid.org/0000-0002-0006-9644
Aretha FiebigDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, United States.
Sean CrossonDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, United States.ORCID http://orcid.org/0000-0002-1727-322X
University of Chicago · US

Funding

Technology CoreU19AI107792 · NIAID · UNIVERSITY OF CHICAGO · PI CROSSON, SEAN · 2013 to 2017
$4.3M
Intergrated control of Caulobacter cell physiology by visible light and stressR01GM087353 · NIGMS · UNIVERSITY OF CHICAGO · PI CROSSON, SEAN · 2009 to 2018
$2.8M
NIAID NIH HHS U19 AI107792NIGMS NIH HHS R01 GM087353NIH HHS 1R01GM087353NIH HHS U19AI107792
6 · The paper itself

Abstract

Cells adapt to shifts in their environment by remodeling transcription. Measuring changes in transcription at the genome scale is now routine, but defining the functional significance of individual genes within large gene expression datasets remains a major challenge. We applied a network-based algorithm to interrogate publicly available gene expression data to predict genes that serve major functional roles in

Indexed as

Transcription, GeneticCatalaseCaulobacter crescentusCellular MicroenvironmentGene Expression Regulation, BacterialGene Regulatory NetworksHydrogen PeroxideOsmotic PressureOxidative StressPeroxidaseRNA, MessengerCatalaseHydrogen PeroxidePeroxidaseRNA, MessengeralphaproteobacteriabiochemistryCaulobacterchemical biologygene regulationinfectious diseasemicrobiologynetworksmall RNAstress response

Identifiers

PMID29537368
PMCPMC5869019
OpenAlexW2765407344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.