Evidence map›Paper›PMID 29537340›Full record

ReviewTherapeutic advances in respiratory disease

Single-inhaler triple therapy utilizing the once-daily combination of fluticasone furoate, umeclidinium and vilanterol in the management of COPD: the current evidence base and future prospects.

Mario Malerba, Matteo Nardin, Giuseppe Santini, Nadia Mores, Alessandro Radaeli, Paolo Montuschi

Open access · goldAbstract readReview
In one paragraph

Review in Therapeutic advances in respiratory disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Clinical Concepts for Triple Therapy Use in Patients with COPD: A Delphi Consensus.International journal of chronic obstructive pulmonary disease · 2023
    Article
  4. Article
  5. A Delphi Consensus Document on the Use of Single-Inhaler Fixed-Dose Triple Therapies in COPD Patients.International journal of chronic obstructive pulmonary disease · 2020
    Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Mario MalerbaDepartment of Translational Medicine-Respiratory Medicine, University of Piemonte Orientale, Novara/Vercelli, Italy.
Matteo NardinDepartment of Internal Medicine, University of Brescia, Brescia, Italy.
Giuseppe SantiniDepartment of Pharmacology, Catholic University of the Sacred Heart, Agostino Gemelli University Hospital Foundation, Rome, Italy.
Nadia MoresDepartment of Pharmacology, Catholic University of the Sacred Heart, Agostino Gemelli University Hospital Foundation, Rome, Italy.
Alessandro RadaeliDepartment of Emergency Medicine, ASST Spedali Civili di Brescia, Brescia, Italy.
Paolo MontuschiDepartment of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Agostino Gemelli, University Hospital Foundation, Largo Francesco Vito, 1 - 00168, Rome, Italy.
Agostino Gemelli University Polyclinic · ITAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITUniversità Cattolica del Sacro Cuore · ITUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITUniversity of Brescia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Maintenance pharmacological treatment for stable chronic obstructive pulmonary disease (COPD) is based on inhaled drugs, including long-acting muscarinic receptor antagonists (LAMA), long-acting β

Indexed as

Administration, InhalationAdrenergic beta-2 Receptor AgonistsAndrostadienesBenzyl AlcoholsBronchodilator AgentsChlorobenzenesDrug CombinationsEvidence-Based MedicineGlucocorticoidsHumansLungMuscarinic AntagonistsNebulizers and VaporizersPulmonary Disease, Chronic ObstructiveQuinuclidinesRecovery of FunctionAdrenergic beta-2 Receptor AgonistsAndrostadienesBenzyl AlcoholsBronchodilator AgentsChlorobenzenesDrug Combinationsfluticasone furoateGlucocorticoidsGSK573719Muscarinic AntagonistsQuinuclidinesvilanterolCOPDfluticasonepharmacotherapysingle-inhalertriple therapyumeclidiniumvilanterol

Identifiers

PMID29537340
PMCPMC5941662
OpenAlexW2793753219

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.