Evidence map›Paper›PMID 29536947›Full record

ArticleBiomedical materials (Bristol, England)2018

Biofabrication of injectable fibrin microtissues for minimally-invasive therapies: application of surfactants.

Ramkumar T Annamalai, Tapan Naik, Haley Prout, Andrew J Putnam, Jan P Stegemann

Abstract read
In one paragraph

Article in Biomedical materials (Bristol, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Fabrication and characterization of osteogenic function of progenitor cell-laden gelatin microcarriers.Journal of biomedical materials research. Part B, Applied biomaterials · 2022
    Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ramkumar T AnnamalaiDepartment of Biomedical Engineering, University of Michigan, 1101 Beal Ave., Ann Arbor MI, United States of America.ORCID 0000-0002-9880-3973
Tapan NaikDepartment of Biomedical Engineering, University of Michigan, 1101 Beal Ave., Ann Arbor MI, United States of America.
Haley ProutDepartment of Biomedical Engineering, University of Michigan, 1101 Beal Ave., Ann Arbor MI, United States of America.
Andrew J PutnamDepartment of Biomedical Engineering, University of Michigan, 1101 Beal Ave., Ann Arbor MI, United States of America.
Jan P StegemannDepartment of Biomedical Engineering, University of Michigan, 1101 Beal Ave., Ann Arbor MI, United States of America.
University of Michigan · US

Funding

Bone Regeneration Using Osteogenic and Vasculogenic Tissue ModulesR01AR062636 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI STEGEMANN, JAN P. · 2014 to 2018
$1.7M
Preformed vascular modules designed for inosculation with host tissueR01HL118259 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PUTNAM, ANDREW J, STEGEMANN, JAN P. · 2013 to 2016
$1.5M
NHLBI NIH HHS R01 HL118259NIAMS NIH HHS R01 AR062636
6 · The paper itself

Abstract

Microtissues created from the protein fibrin and containing embedded cells can be used in modular tissue engineering approaches to create larger, hierarchical and complex tissue structures. In this paper we demonstrate an emulsification-based method for the production of such fibrin microtissues containing fibroblasts (FB) and endothelial cells (EC) and designed to promote tissue vascularization. Surfactants can be beneficial in the microtissue fabrication process to reduce aggregation and to facilitate recovery of microtissues from the emulsion, thereby increasing yield. The nonionic surfactants Pluronic L101

Indexed as

InjectionsAnimalsCattleCell SurvivalDose-Response Relationship, DrugEmulsionsEndothelial CellsFibrinFibrinogenFibroblastsGelsHumansHydrogelsPolyethylene GlycolsPolymersRegenerationEmulsionsFibrinFibrinogenGelsHydrogelsPolyethylene GlycolsPolymersSurface-Active Agents

Identifiers

PMID29536947
PMCPMC5938738
OpenAlexW2794103299

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.