Evidence map›Paper›PMID 29536829›Full record

ReviewEcoSal Plus2018

Pili Assembled by the Chaperone/Usher Pathway in

Glenn T Werneburg, David G Thanassi

Abstract readReview
In one paragraph

Review in EcoSal Plus, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. A quorum-sensing molecule fromProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Avian PathogenicVeterinary sciences · 2025
    Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. FimC binds to the promoter region ofFrontiers in cellular and infection microbiology · 2025
    Article
  13. Article
  14. Distribution ofInternational journal of molecular sciences · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Urinary Tract Infections Caused by UropathogenicInternational journal of molecular sciences · 2023
    Review
  20. Genomic Characterization ofAntibiotics (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Glenn T WerneburgDepartment of Molecular Genetics and Microbiology.
David G ThanassiDepartment of Molecular Genetics and Microbiology.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008444 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI FROHMAN, MICHAEL A. · 1992 to 2024
$12.6M
Mechanism of the Usher in Assembly and Secretion of PiliR01GM062987 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI David G Thanassi · 2001 to 2026
$7.7M
Small Molecule Inhibition of Pilus Biogenesis by Pathogenic BacteriaR21AI121639 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI THANASSI, DAVID G · 2016 to 2017
$406k
Catalytic mechanism of the usher in pilus biogenesis by uropathogenic E. coliF30AI112252 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI WERNEBURG, GLENN THOMAS · 2015 to 2018
$162k
NIAID NIH HHS F30 AI112252NIAID NIH HHS R21 AI121639NIGMS NIH HHS R01 GM062987NIGMS NIH HHS T32 GM008444
6 · The paper itself

Abstract

Gram-negative bacteria assemble a variety of surface structures, including the hair-like organelles known as pili or fimbriae. Pili typically function in adhesion and mediate interactions with various surfaces, with other bacteria, and with other types of cells such as host cells. The chaperone/usher (CU) pathway assembles a widespread class of adhesive and virulence-associated pili. Pilus biogenesis by the CU pathway requires a dedicated periplasmic chaperone and integral outer membrane protein termed the usher, which forms a multifunctional assembly and secretion platform. This review addresses the molecular and biochemical aspects of the CU pathway in detail, focusing on the type 1 and P pili expressed by uropathogenic

Indexed as

AnimalsFimbriae, BacterialFimbriae ProteinsHumansMetabolic Networks and PathwaysMiceModels, MolecularMolecular ChaperonesSalmonellaUropathogenic Escherichia coliFimbriae ProteinsMolecular Chaperones

Identifiers

PMID29536829
PMCPMC5940347

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.