ArticleAnalytical chemistry2018
Negative Selection by Spiral Inertial Microfluidics Improves Viral Recovery and Sequencing from Blood.
Article in Analytical chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- A Universal and Single-Step (De)Molding Sorting Chip Integrating Inertial and Deterministic Lateral Displacement Units.Bioengineering (Basel, Switzerland) · 2025Article
- The planarian dorsal-ventral boundary regulates anterior-posterior axis growth and patterning.PLoS biology · 2025Article
- Separation of Activated T Cells Using Multidimensional Double Spiral (MDDS) Inertial Microfluidics for High-Efficiency CAR T Cell Manufacturing.Analytical chemistry · 2024Article
- A review on inertial microfluidic fabrication methods.Biomicrofluidics · 2023Review
- Blood component separation in straight microfluidic channels.Biomicrofluidics · 2023Article
- High-Throughput Cell Concentration Using A Piezoelectric Pump in Closed-Loop Viscoelastic Microfluidics.Micromachines · 2021Article
- Inertial Microfluidics Enabling Clinical Research.Micromachines · 2021Review
- Fully-automated and field-deployable blood leukocyte separation platform using multi-dimensional double spiral (MDDS) inertial microfluidics.Lab on a chip · 2020Article
- Recent advances in lab-on-a-chip technologies for viral diagnosis.Biosensors & bioelectronics · 2020Review
- Leukocyte function assessed via serial microlitre sampling of peripheral blood from sepsis patients correlates with disease severity.Nature biomedical engineering · 2019Article
- Rapid and Safe Isolation of Human Peripheral Blood B and T Lymphocytes through Spiral Microfluidic Channels.Scientific reports · 2019Article
- New insights into the physics of inertial microfluidics in curved microchannels. II. Adding an additive rule to understand complex cross-sections.Biomicrofluidics · 2019Article
- Liquid biopsy for minimal residual disease detection in leukemia using a portable blast cell biochip.NPJ precision oncology · 2019Article
- Progress of Inertial Microfluidics in Principle and Application.Sensors (Basel, Switzerland) · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
In blood samples from patients with viral infection, it is often important to separate viral particles from human cells, for example, to minimize background in performing viral whole genome sequencing. Here, we present a microfluidic device that uses spiral inertial microfluidics with continuous circulation to separate host cells from viral particles and free nucleic acid. We demonstrate that this device effectively reduces white blood cells, red blood cells, and platelets from both whole blood and plasma samples with excellent recovery of viral nucleic acid. Furthermore, microfluidic separation leads to greater viral genome coverage and depth, highlighting an important application of this device in processing clinical samples for viral genome sequencing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.