Evidence map›Paper›PMID 29536542›Full record

ArticleThe Laryngoscope2018

Prognostic factors for human papillomavirus-positive and negative oropharyngeal carcinomas.

Linda X Yin, Gypsyamber D'Souza, William H Westra, Steven J Wang, Annemieke van Zante, Yuehan Zhang, Eleni M Rettig, William R Ryan, Patrick K Ha, Alicia Wentz and 3 more

Open access · greenAbstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Laryngoscope, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Linda X YinDepartment of Otorhinolaryngology, Mayo Clinic, Rochester, Minnesota.ORCID 0000-0001-8515-2051
Gypsyamber D'SouzaDepartment of Epidemiology, Johns Hopkins University, Baltimore, Maryland.
William H WestraDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland.
Steven J WangDepartment of Otolaryngology-Head and Neck Surgery, University of Arizona, Tucson, Arizona.
Annemieke van ZanteDepartment of Pathology, University of California-San Francisco, San Francisco, California, U.S.A.
Yuehan ZhangDepartment of Epidemiology, Johns Hopkins University, Baltimore, Maryland.
Eleni M RettigDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland.
William R RyanDepartment of Otolaryngology-Head and Neck Surgery, University of California-San Francisco, San Francisco, California, U.S.A.
Patrick K HaDepartment of Otolaryngology-Head and Neck Surgery, University of California-San Francisco, San Francisco, California, U.S.A.
Alicia WentzDepartment of Epidemiology, Johns Hopkins University, Baltimore, Maryland.
Wayne KochDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland.ORCID 0000-0002-9499-1516
David W EiseleDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland.
Carole FakhryDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland.
Johns Hopkins University · USUniversity of California, San Francisco · USMayo Clinic · USUniversity of Arizona · US

Funding

TUMOR SUPPRESOR GENE PROMOTER HYPERMETHYLATION FOR DETECTION OF HEAD AND NECKP50DE019032 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI SIDRANSKY, DAVID · 2007 to 2016
$27.1M
Impacting the oral HPV continuum: prevention, screening, and early detectionR35DE026631 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI D'SOUZA, GYPSYAMBER · 2016 to 2023
$8.4M
NIDCR NIH HHS P50 DE019032NIDCR NIH HHS R35 DE026631
6 · The paper itself

Abstract

objectives/hypothesisHuman papillomavirus (HPV)-positive and HPV-negative oropharyngeal squamous cell carcinoma (OPSCC) are distinct disease entities. Prognostic factors specific to each entity have not been adequately explored. Goals for this study were: 1) to determine whether HPV-positive and HPV-negative OPSCCs have distinct prognostic factors, and 2) to explore the prognostic significance of sex and race in OPSCC after HPV stratification STUDY

designRetrospective case series.

methodsA retrospective review of 239 incident OPSCC patients from 1995 to 2012, treated at Johns Hopkins and University of California-San Francisco was conducted. Women and nonwhite races were oversampled. All analyses were stratified by tumor HPV in situ hybridization status. The effects of sex and race on survival were considered in Kaplan-Meier and unadjusted and adjusted Cox regression models.

resultsOne hundred thirty-four (56.1%) OPSCC patients were HPV positive. On univariate analysis, women had better overall survival than men among HPV-positive (hazard ratio [HR]: 0.47, 95% confidence interval [CI]: 0.20-1.07; P = .06) but not HPV-negative (HR: 0.73, 95% CI: 0.43-1.24; P = .24) OPSCCs. On multivariate analysis, women with HPV-positive OPSCCs remained at lower risk of death (adjusted hazard ratio [aHR]: 0.34, 95% CI: 0.12-0.96; P = .04). Survival did not vary significantly by race among HPV-positive patients. Among HPV-negative patients, Hispanic patients had significantly better survival in unadjusted (HR: 0.27, 95% CI: 0.08-0.91; P = .04) but not adjusted (aHR: 0.93, 95% CI: 0.11-7.36; P = .94) analysis.

conclusionsWomen with HPV-positive OPSCC may have improved overall survival compared to men. Sex does not play a prognostic role in HPV-negative OPSCC. There are no differences in prognosis by race among HPV-positive or HPV-negative patients. LEVEL OF EVIDENCE: 4 Laryngoscope, E287-E295, 2018.

Indexed as

PapillomaviridaeCarcinomaFemaleHispanic or LatinoHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisOropharyngeal NeoplasmsPapillomavirus InfectionsPrognosisProportional Hazards ModelsRacial GroupsRegression AnalysisRetrospective Studieshead and neck oncologyHuman papillomavirusoropharyngealprognostic factorssquamous cell carcinoma

Identifiers

PMID29536542
PMCPMC8929688
OpenAlexW2792941270

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.