Evidence map›Paper›PMID 29536426›Full record

ArticleDiabetes therapy : research, treatment and education of diabetes and related disorders2018

Pioglitazone Improved Insulin Sensitivity and First Phase Insulin Secretion Among Obese and Lean People with Diabetes: A Multicenter Clamp Study.

Xin Qian, Hui Wang, Gangyi Yang, Zhengnan Gao, Yong Luo, Aimei Dong, Fang Zhang, Mingtong Xu, Shiping Liu, Xin Yang and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes therapy : research, treatment and education of diabetes and related disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 2 countries.

Xin QianEndocrinology and Cardiovascular Diseases Center, Fuwai Hospital, Chinese Academy of Medical Sciences, No. 167 North Lishi Road, Xicheng District, Beijing, China.
Hui WangEndocrinology and Cardiovascular Diseases Center, Fuwai Hospital, Chinese Academy of Medical Sciences, No. 167 North Lishi Road, Xicheng District, Beijing, China.
Gangyi YangDepartment of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, No. 76 Linjiang Road, Chongqing, China.
Zhengnan GaoDepartment of Endocrinology, Dalian Municipal Central Hospital, No. 42 Xuegong Street, Shahekou District, Dalian, China.
Yong LuoDepartment of Endocrinology, Chongqing Three Gorges Central Hospital, No. 165 Xincheng Road, Wanzhou District, Chongqing, China.
Aimei DongDepartment of Endocrinology, Peking University First Hospital, No. 8 Xishiku Road, Xicheng District, Beijing, China.
Fang ZhangDepartment of Endocrinology, Peking University Shenzhen Hospital, No. 1120 Lianhua Road, Futian District, Shenzhen, China.
Mingtong XuDepartment of Endocrinology, Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang West Road, Guangzhou, China.
Shiping LiuDepartment of Endocrinology, The Second Xiangya Hospital of Central South University, No. 139 Renmin Middle Road, Changsha, Hunan, China.
Xin YangDepartment of Information Systems, Statistics, and Management Science, Culverhouse College of Commerce and Business Administration, The University of Alabama, Tuscaloosa, AL, USA.
Yanyan ChenEndocrinology and Cardiovascular Diseases Center, Fuwai Hospital, Chinese Academy of Medical Sciences, No. 167 North Lishi Road, Xicheng District, Beijing, China.
Guangwei LiEndocrinology and Cardiovascular Diseases Center, Fuwai Hospital, Chinese Academy of Medical Sciences, No. 167 North Lishi Road, Xicheng District, Beijing, China. guangwei_li45@126.com.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNCentral South University · CNChongqing Medical University · CNChongqing Three Gorges Central Hospital · CNDalian Municipal Central Hospital · CNPeking University First Hospital · CNPeking University Shenzhen Hospital · CNSun Yat-sen Memorial Hospital · CNUniversity of Alabama · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTo investigate the effects of pioglitazone (PIO) on insulin resistance and first phase insulin secretion among obese and lean Chinese people with type 2 diabetes mellitus (T2DM).

methodsSixty-eight drug-naïve patients with T2DM were treated with PIO for 16 weeks. Before and after the treatment, insulin sensitivity was evaluated by the euglycemic hyperinsulinemic clamp test. Plasma insulin levels at 0, 3, 5, 7, and 10 min during intravenous glucose tolerance test were determined to calculate the first phase insulin secretion and pancreatic β-cell function. Circulating adiponectin levels were quantified.

resultsIn both the lean and the obese patients with T2DM, the reduction of HbA

conclusionA 16-week treatment of PIO significantly increased insulin sensitivity and β-cell function in the lean group as well as in the obese group among Chinese T2DM patients, demonstrating that both lean and obese diabetic adults would profit from PIO.

trial registrationThe ChiCTR registry number is ChiCTR-OPC-17011571.

fundingTakeda Pharmaceutical Co. Ltd. and Pfizer Pharmaceutical Co. Ltd.

Indexed as

First phaseInsulin resistanceInsulin secretionPioglitazone

Identifiers

PMID29536426
PMCPMC6104278
OpenAlexW2793346314

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.