ArticleWorld journal of pediatrics : WJP2018
Morbidity and mortality of coagulase-negative staphylococcal sepsis in very-low-birth-weight infants.
Article in World journal of pediatrics : WJP, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Contemporary Trends in Global Mortality of Sepsis Among Young Infants Less Than 90 Days: A Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2022Pooled it
- Pooled it
- Epidemiology, microbiological profile, and antimicrobial resistance patterns of culture-proven neonatal sepsis in a tertiary NICU.BMC pediatrics · 2026Article
- Changes in mortality in very preterm neonates in a single institution in Dallas, Texas, 1977-2024: a cohort study.Pediatric research · 2026Article
- Which Bacterial Agent Is More Influential in the Development of Retinopathy of Prematurity: Gram-Positive or Gram-Negative?Children (Basel, Switzerland) · 2026Article
- CoNS blood culture isolates from very preterm infants: antibiotic susceptibility, synergy testing andJAC-antimicrobial resistance · 2026Article
- Antibiotic exposure and infection epidemiology among newborns with congenital diaphragmatic hernia.Journal of perinatology : official journal of the California Perinatal Association · 2025Observational
- [Recommendations for antibiotic use in hospitalized preterm infants with late-onset sepsis in the neonatal intensive care unit].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- Variation in antibiotic consumption in very preterm infants-a 10 year population-based study.The Journal of antimicrobial chemotherapy · 2024Article
- Article
- Association of Positive Bacterial Cultures Obtained from the Throat, Anus, Ear, Bronchi and Blood in Very-Low-Birth-Weight Premature Infants with Severe Retinopathy of Prematurity-Own Observations.Journal of clinical medicine · 2023Article
- Cardiorespiratory signature of neonatal sepsis: development and validation of prediction models in 3 NICUs.Pediatric research · 2023Article
- Clinical Characteristics and Outcomes of Persistent Staphylococcal Bacteremia in a Tertiary Care Hospital.Antibiotics (Basel, Switzerland) · 2023Article
- Late-Onset Sepsis Mortality among Preterm Infants: Beyond Time to First Antibiotics.Microorganisms · 2023Article
- Determinants of morbidity and mortality related to health care-associated primary bloodstream infections in neonatal intensive care units: a prospective cohort study from the SEPREVEN trial.Frontiers in pediatrics · 2023Article
- Review
- Early and late onset sepsis and retinopathy of prematurity in a cohort of preterm infants.Scientific reports · 2022Article
- Persistent Coagulase-Negative Staphylococcal Bacteremia in Neonates: Clinical, Microbiological Characteristics and Changes within a Decade.Antibiotics (Basel, Switzerland) · 2022Article
- Mortality Risk Factors of Early Neonatal Sepsis During COVID-19 Pandemic.Infection and drug resistance · 2022Article
- Vital signs as physiomarkers of neonatal sepsis.Pediatric research · 2022Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundCoagulase-negative staphylococci (CoNS) are the most common cause of late-onset sepsis in the neonatal intensive care unit (NICU) and usually require vancomycin treatment. Our objective was to determine whether CoNS are associated with neonatal morbidity and mortality.
methodsThis was a retrospective cohort study of very-low-birth-weight (VLBW, ≤ 1500 g) infants from 1989 to 2015. Exclusion criteria were major congenital anomaly or death within 72 h. CoNS was considered a pathogen if recovered from ≥ 2 cultures, or 1 culture if treated for ≥ 5 days and signs of sepsis were present. Logistic regression was used to examine factors associated with morbidity and mortality.
resultsOf 2242 VLBW infants, 285 (12.7%) had late-onset sepsis. CoNS (125, 44%), Staphylococcus aureus (52, 18%), and Escherichia coli (36, 13%) were the most commonly recovered organisms. In multivariate analysis, CoNS sepsis was not associated with mortality [OR 0.6 (95% CI 0.2-2.6)), but sepsis with other organisms was [OR 4.5 (95% CI 2.6-8.0)]. CoNS sepsis was associated with longer hospitalization but not risk for bronchopulmonary dysplasia, intraventricular hemorrhage, or retinopathy of prematurity.
conclusionCoNS sepsis was not associated with mortality or morbidities other than length of stay. These findings support vancomycin-reduction strategies in the NICU.
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