Evidence map›Paper›PMID 29536339›Full record

ArticleImmunologic research2018

The human breast cancer-associated protein, the prolactin-inducible protein (PIP), regulates intracellular signaling events and cytokine production by macrophages.

Olivia Ihedioha, Anne A Blanchard, Jyoti Balhara, Ifeoma Okwor, Ping Jia, Jude Uzonna, Yvonne Myal

Abstract read
PubMed Publisher
In one paragraph

Article in Immunologic research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. The crucial role of prolactin-lactogenic hormone in Covid-19.Molecular and cellular biochemistry · 2022
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Olivia IhediohaDepartment of Pathology, University of Manitoba, Winnipeg, Manitoba, Canada.
Anne A BlanchardDepartment of Pathology, University of Manitoba, Winnipeg, Manitoba, Canada.ORCID 0000-0002-6752-6280
Jyoti BalharaDepartment of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada.
Ifeoma OkworDepartment of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada.
Ping JiaDepartment of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada.
Jude UzonnaDepartment of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada. jude.uzonna@umanitoba.ca.
Yvonne MyalDepartment of Pathology, University of Manitoba, Winnipeg, Manitoba, Canada.
University of Manitoba · CA

Funding

CIHR
6 · The paper itself

Abstract

The prolactin-inducible protein (PIP) is considered a valuable biomarker that is associated with both benign and malignant pathological conditions of the mammary gland. The function of PIP in breast tumorigenesis remains unknown; however, evidence from our laboratory and others suggest that it regulates host immunity. Studies with PIP-deficient (PIP

Indexed as

AnimalsExtracellular Signal-Regulated MAP KinasesFemaleHumansInterferon-gammaLipopolysaccharidesMacrophagesMammary Neoplasms, AnimalMAP Kinase Signaling SystemMiceMice, KnockoutProteinsSTAT Transcription FactorsTh1 CellsToll-Like Receptor 4Extracellular Signal-Regulated MAP KinasesIFNG protein, mouseInterferon-gammaLipopolysaccharidesProteinsSMGP-PIP protein, mouseSTAT Transcription FactorsTlr4 protein, mouseToll-Like Receptor 4Breast cancerCell-mediated immunityInterferon gammaLipopolysaccharideMacrophagesProlactin-inducible protein

Identifiers

PMID29536339
OpenAlexW2793154232

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.