ArticleEJNMMI physics2018
Feasibility study of a novel general purpose CZT-based digital SPECT camera: initial clinical results.
Article in EJNMMI physics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Radiopharmaceuticals for PET and SPECT Imaging: A Literature Review over the Last Decade.International journal of molecular sciences · 2022Pooled it
- Quantitative accuracy ofEJNMMI physics · 2026Article
- Instrumentation Digital Twins in PET and SPECT Imaging: Current Status, Challenges, and Future Directions.Computational and structural biotechnology journal · 2026Review
- Analytical methods for system matrix calculation and spatial resolution evaluation of DC-SPECT system.Physics in medicine and biology · 2025Article
- Letter to the Editor: EANM position paper on challenges and opportunities of full-ring 360° CZT bone imaging: it's time to let go of planar whole-body bone imaging.European journal of nuclear medicine and molecular imaging · 2025Article
- A review of state-of-the-art resolution improvement techniques in SPECT imaging.EJNMMI physics · 2025Review
- Improving the image quality of short-time bone SPECT using cadmium-zinc-telluride detectors with SwiftScan.Asia Oceania journal of nuclear medicine & biology · 2025Article
- Recent advances in radionuclide medical imaging techniques.Frontiers in medicine · 2025Review
- Bias and precision of SPECT-basedEJNMMI physics · 2024Article
- 360° CZT-SPECT/CT cameras:EJNMMI physics · 2024Article
- EANM perspectives for CZT SPECT in brain applications.European journal of nuclear medicine and molecular imaging · 2024Article
- Verification of reprojected planar images generated from a ring-configured cadmium zinc telluride gamma camera in scintigraphy for diagnosing transthyretin cardiac amyloidosis.European heart journal. Imaging methods and practice · 2024Article
- Performance study of a 360° CZT camera for monitoringEJNMMI physics · 2023Article
- Simulation studies of a full-ring, CZT SPECT system for whole-body imaging ofMedical physics · 2023Article
- Dynamic cardiac SPECT with flow measurement using 3D-ring CZT: when SPECT is inspired by PET.European journal of nuclear medicine and molecular imaging · 2023Article
- Joint estimation of interaction position and energy deposition in semiconductor SPECT imaging sensors using fully connected neural network.Physics in medicine and biology · 2023Article
- Same same but different: dopamine transporter SPECT on scanners with CZT vs. NaI detectors.EJNMMI research · 2023Article
- Feasibility of Imaging Small Animals on a 360° Whole-Body Cadmium Zinc Telluride SPECT Camera: a Phantom Study.Molecular imaging and biology · 2022Article
- Quantitative Scintigraphy Imaging of Lingual Raynaud's Phenomenon Using 3-Dimensional-Ring Cadmium-Zinc-Telluride Single-Photon Emission Computed Tomography/Computed Tomography.Tomography (Ann Arbor, Mich.) · 2022Article
- Design Study of an Ultrahigh Resolution Brain SPECT System Using a Synthetic Compound-Eye Camera Design With Micro-Slit and Micro-Ring Apertures.IEEE transactions on medical imaging · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe performance of a prototype novel digital single-photon emission computed tomography (SPECT) camera with multiple pixelated CZT detectors and high sensitivity collimators (Digital SPECT; Valiance X12 prototype, Molecular Dynamics) was evaluated in various clinical settings. Images obtained in the prototype system were compared to images from an analog camera fitted with high-resolution collimators. Clinical feasibility, image quality, and diagnostic performance of the prototype were evaluated in 36 SPECT studies in 35 patients including bone (n = 21), brain (n = 5), lung perfusion (n = 3), and parathyroid (n = 3) and one study each of sentinel node and labeled white blood cells. Images were graded on a scale of 1-4 for sharpness, contrast, overall quality, and diagnostic confidence.
resultsDigital CZT SPECT provided a statistically significant improvement in sharpness and contrast in clinical cases (mean score of 3.79 ± 0.61 vs. 3.26 ± 0.50 and 3.92 ± 0.29 vs. 3.34 ± 0.47 respectively, p < 0.001 for both). Overall image quality was slightly higher for the digital SPECT but not statistically significant (3.74 vs. 3.66).
conclusionCZT SPECT provided significantly improved image sharpness and contrast compared to the analog system in the clinical settings evaluated. Further studies will evaluate the diagnostic performance of the system in large patient cohorts in additional clinical settings.
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