Evidence map›Paper›PMID 29536218›Full record

ArticleInflammopharmacology2018

Pharmacological mechanisms underlying gastroprotective activities of binapthyl diselenide in Wistar rats.

Mohammad Ibrahim, Musadiq Ibrahim, Niaz Muhammad, Muhammad Ishaq Ali Shah, Gerlânia de Oliveira Leite, Joao B T Rocha

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Article in Inflammopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mohammad IbrahimPrograma de Pós-Graduação em Ciências Biológicas- Bioquímica Toxicológica, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, CEP 97105-900, Brazil. dribrahim@awkum.edu.pk.
Musadiq IbrahimDepartment of Chemistry and Division of Biochemistry and Life Science, University of Glasgow, Glasgow, G128QQ, UK.
Niaz MuhammadPrograma de Pós-Graduação em Ciências Biológicas- Bioquímica Toxicológica, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, CEP 97105-900, Brazil.
Muhammad Ishaq Ali ShahDepartment of Chemistry, Abdul Wali Khan University Mardan (AWKUM) KPK, Mardan, Pakistan.
Gerlânia de Oliveira LeitePrograma de Pós-Graduação em Ciências Biológicas- Bioquímica Toxicológica, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, CEP 97105-900, Brazil.
Joao B T RochaPrograma de Pós-Graduação em Ciências Biológicas- Bioquímica Toxicológica, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, CEP 97105-900, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Selenium (Se) is a dietary essential trace element with important biological roles. It is a nutrient related to the complex metabolic and enzymatic functions. Organoselenium compounds have been reported to have anti-ulcer activity and used as drug for the treatment of gastrointestinal disorders. The antiulcer activity of binapthyl diselenide (NapSe)2 was investigated in ethanol-induced gastric lesions in rats. A number of markers of oxidative stress were examined in rats stomach including thiobarbituric acid reactive species (TBARS), catalase (CAT), superoxide dismutase (SOD), non-protein thiol groups (NPSH) and ascorbic acid. (NapSe)2 was found to be significantly restoring the deficits in the antioxidant defense mechanisms (CAT, SOD, NPSH and ascorbic acid), and suppressed lipid peroxidation in rat stomach resulting from EtOH administration. It is experimentally concluded that ethanol exposure causes alterations in the antioxidant defense system and induces oxidative stress in rat stomach. These studies establish a promising foundation for investigating and understanding the beneficial effects of organoselenium compounds on human health. Moreover, (NaPSe)

Indexed as

AnimalsAntioxidantsAnti-Ulcer AgentsCatalaseDisease Models, AnimalEthanolLipid PeroxidationMaleOrganoselenium CompoundsOxidative StressRatsRats, WistarStomach UlcerSuperoxide DismutaseThiobarbituric Acid Reactive SubstancesAntioxidantsAnti-Ulcer Agentsbinaphthyl diselenideCatalaseEthanolOrganoselenium CompoundsSuperoxide DismutaseThiobarbituric Acid Reactive SubstancesAnti-ulcer activityLipid peroxidationSelenium: Oxidative stress: TBARS: CATSOD

Identifiers

PMID29536218

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.