SynthesisPediatric surgery international2018
Are prophylactic anti-reflux medications effective after esophageal atresia repair? Systematic review and meta-analysis.
Synthesis in Pediatric surgery international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03619408 (Management of Esophagitis Following Repair of Esophageal Atresia), which is not on this map. Cited by 10 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Management of Esophagitis Following Repair of Esophageal Atresia
Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Management of gastroesophageal reflux disease following esophageal atresia surgery: a systematic review.Pediatric surgery international · 2025Pooled it
- Gender and birth weight as risk factors for anastomotic stricture after esophageal atresia repair: a systematic review and meta-analysis.BMC pediatrics · 2020Pooled it
- Risk factors for anastomotic complications following thoracoscopic repair of type III esophageal atresia in neonates: a single-center retrospective cohort study.Frontiers in pediatrics · 2026Article
- Multidisciplinary coordination of care for children with esophageal atresia and tracheoesophageal fistula.Journal of child health care : for professionals working with children in the hospital and community · 2025Article
- Article
- Effect of proton pump inhibitors in infants with esophageal atresia on the gut microbiome: a pilot cohort.Gut pathogens · 2022Article
- Prevalence of acid gastroesophageal reflux disease in infants with esophageal atresia/tracheoesophageal fistula.Pediatric research · 2022Article
- The association between polymorphisms in PITX2 and congenital esophageal atresia susceptibility.American journal of translational research · 2021Article
- Evaluation of Gastroesophageal Reflux in Children Born With Esophageal Atresia Using pH and Impedance Monitoring.Journal of pediatric gastroenterology and nutrition · 2019Article
- Congenital Heart Disease and Its Impact on the Development of Anastomotic Strictures after Reconstruction of Esophageal Atresia.Gastroenterology research and practice · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
purposeGastroesophageal reflux after surgical repair of esophageal atresia (EA) can be associated with complications, such as esophageal stricture. Recent guidelines recommend prophylactic anti-reflux medication (PARM) after EA repair. However, the effectiveness of PARM is still unclear. The aim of this study was to review evidence surrounding the use of PARM in children operated for EA.
methodsWe performed a systematic review and meta-analysis. We searched Medline, EMBASE, and the Cochrane Databases from inception until the end of 2016 for comparative studies of PARM versus no PARM (control). Primary outcome was postoperative esophageal stricture. Quality of evidence was assessed using GRADE system.
resultsWe identified four observational studies that focused on esophageal stricture as an outcome. A total of 362 patients were included in meta-analysis. There was no significant difference in esophageal stricture rates between PARM and control (OR = 1.14; 95% CI = 0.61-2.13; p = 0.68; I
conclusionsOur results indicate that PARM does not reduce the incidence of esophageal stricture after EA repair. Future well-controlled prospective studies are needed to obtain higher quality evidence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.