Evidence map›Paper›PMID 29536167›Full record

ArticleVirchows Archiv : an international journal of pathology2018

CD47 expression in Epstein-Barr virus-associated gastric carcinoma: coexistence with tumor immunity lowering the ratio of CD8

Hiroyuki Abe, Ruri Saito, Takashi Ichimura, Akiko Iwasaki, Sho Yamazawa, Aya Shinozaki-Ushiku, Teppei Morikawa, Tetsuo Ushiku, Hiroharu Yamashita, Yasuyuki Seto and 1 more

Abstract read
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In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. CD47 and FOXP3Cancers · 2026
    Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Unusual or Uncommon Histology of Gastric Cancer.Journal of gastric cancer · 2024
    Review
  7. [Latest Findings on the Role of CD47 in Tumor Immune Evasion and Related Targeted Therapies].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2023
    Review
  8. Article
  9. Role of immune escape in different digestive tumours.World journal of clinical cases · 2021
    Review
  10. Review
  11. Thirty years of Epstein-Barr virus-associated gastric carcinoma.Virchows Archiv : an international journal of pathology · 2020
    Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Hiroyuki AbeDepartment of Pathology, The University of Tokyo Hospital, Tokyo, Japan.
Ruri SaitoDepartment of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Takashi IchimuraDepartment of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Akiko IwasakiDepartment of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Sho YamazawaDepartment of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Aya Shinozaki-UshikuDepartment of Pathology, The University of Tokyo Hospital, Tokyo, Japan.
Teppei MorikawaDepartment of Pathology, The University of Tokyo Hospital, Tokyo, Japan.
Tetsuo UshikuDepartment of Pathology, The University of Tokyo Hospital, Tokyo, Japan.
Hiroharu YamashitaDepartment of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Yasuyuki SetoDepartment of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Masashi FukayamaDepartment of Pathology, The University of Tokyo Hospital, Tokyo, Japan. mfukayama-tky@umin.org.
The University of Tokyo · JPUniversity of Tokyo Hospital · JPTeikyo University · JP

Funding

Japan Society for the Promotion of Science 16K19074Japan Society for the Promotion of Science 26253021Japan Society for the Promotion of Science 26860232
6 · The paper itself

Abstract

Epstein-Barr virus-associated gastric carcinoma (EBVaGC) frequently harbors dense lymphocytic infiltration, suggesting a specific microenvironment allowing coexistence with tumor immunity. CD47, which mediates the "do not eat me" signal in innate immunity, is also important in adaptive anti-tumor immunity. We investigated the significance of CD47 in EBVaGC compared with EBV-negative gastric cancer and the correlation with various immune cells. By immunohistochemistry of CD47, high, low, and negative expression was observed in 24, 63, and 12% of EBVaGC (n = 41), while 11, 49, and 39% of EBV-negative gastric cancer (n = 262), respectively, indicating that high expression of CD47 in cancer cells was significantly frequent and increased in EBVaGC (P = 0.043). In contrast to EBV-negative gastric carcinoma in which no significant correlation was observed between CD47 and survival, high expression of CD47 correlated significantly with worse disease-specific survival (P = 0.011) and overall survival (P = 0.013) in EBVaGC. To further clarify the role of CD47 expression in EBVaGC, digital image analysis of immune cell infiltration revealed that high CD47 expression was correlated with a lower ratio of CD8

Indexed as

AdenocarcinomaAdultAgedCD47 AntigenCD8-Positive T-LymphocytesEpstein-Barr Virus InfectionsFemaleForkhead Transcription FactorsHerpesvirus 4, HumanHumansKaplan-Meier EstimateLymphocytes, Tumor-InfiltratingMaleMiddle AgedProportional Hazards ModelsStomach NeoplasmsCD47 AntigenCD47 protein, humanForkhead Transcription FactorsFOXP3 protein, humanCD47CD8Epstein-Barr virusFoxp3Gastric carcinomaTumor immunity

Identifiers

PMID29536167
OpenAlexW2789488855

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.