Evidence map›Paper›PMID 29535835›Full record

ArticleOncotarget2018

Curcuminoid submicron particle ameliorates cognitive deficits and decreases amyloid pathology in Alzheimer's disease mouse model.

Yi-Heng Tai, Yu-Yi Lin, Kai-Chen Wang, Chao-Lin Chang, Ru-Yin Chen, Chia-Chu Wu, Irene H Cheng

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Yi-Heng Tai *Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan.
Yu-Yi Lin *Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan.
Kai-Chen Wang *Department of Neurology, Cheng-Hsin General Hospital, Taipei, Taiwan.
Chao-Lin ChangFood Industry Research and Development Institute, Hsinchu, Taiwan.
Ru-Yin ChenFood Industry Research and Development Institute, Hsinchu, Taiwan.
Chia-Chu WuFood Industry Research and Development Institute, Hsinchu, Taiwan.
Irene H ChengInstitute of Brain Science, National Yang-Ming University, Taipei, Taiwan.
Food Industry Research and Development Institute · TWNational Yang Ming Chiao Tung University · TWCheng Hsin General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder and is triggered via abnormal accumulation of amyloid-β peptide (Aβ). Aggregated Aβ is responsible for disrupting calcium homeostasis, inducing neuroinflammation, and promoting neurodegeneration. In this study, we generated curcuminoid submicron particle (CSP), which reduce the average size to ~60 nm in diameter. CSP had elevated the bioavailability

Indexed as

Alzheimer’s diseaseamyloidAPP transgenic mousecurcumincurcuminoid submicron particle

Identifiers

PMID29535835
PMCPMC5828200
OpenAlexW2791290286

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.