Evidence map›Paper›PMID 29535789›Full record

ArticleJournal of environmental and public health2018

Long-Term Effects of Environmental Lead Exposure on Blood Pressure and Plasma Soluble Cell Adhesion Molecules in Young Adults: A Follow-Up Study of a Prospective Cohort in Kosovo.

Pashko R Camaj, Joseph H Graziano, Emine Preteni, Dusan Popovac, Nancy LoIacono, Olgica Balac, Pam Factor-Litvak

Open access · hybridAbstract read
In one paragraph

Article in Journal of environmental and public health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Pashko R CamajDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York City, NY, USA.
Joseph H GrazianoDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York City, NY, USA.
Emine PreteniMedical Center, Mitrovica, Kosovo.
Dusan PopovacMedical Faculty, University of Prishtina, Prishtina, Kosovo.
Nancy LoIaconoDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York City, NY, USA.
Olgica BalacDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York City, NY, USA.
Pam Factor-LitvakDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York City, NY, USA.ORCID 0000-0002-7729-1884
Columbia University · USUniversity Clinical Center of Kosovo · XKUniversity of Prishtina · XK

Funding

True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7M
NIEHS NIH HHS P30 ES009089
6 · The paper itself

Abstract

Background and Aims: Epidemiologic studies examining the relationship between environmental lead (Pb) exposure and blood pressure (BP) generally report small associations between blood lead concentration (BPb) and BP. However, these studies are predominantly cross-sectional. In addition, no epidemiologic studies evaluate associations between either current or past Pb exposure and serum levels of markers of systemic inflammation and endothelial dysfunction, including soluble vascular adhesion molecule (sVCAM-1) and soluble intercellular cell adhesion molecule (sICAM-1). We prospectively investigate these associations later in life: Results: We found highly statistically significant association between concurrent BPb and sVCAM-1 in men and a marginally significant association between concurrent PBb and sICAM.-1 in women. We did not find evidence of mediation. Conclusion: Current study results, along with previously reported findings on this cohort, provide evidence for the hypothesis that exposure to Pb leads to small increases in sBP and perhaps to increased circulating levels of sVCAM-1 and sICAM-1 later in life.

Indexed as

Environmental ExposureAdultBlood PressureCell Adhesion MoleculesEnvironmental PollutantsFemaleFollow-Up StudiesHumansKosovoLeadMaleProspective StudiesVascular Cell Adhesion Molecule-1Young AdultCell Adhesion MoleculesEnvironmental PollutantsLeadVascular Cell Adhesion Molecule-1

Identifiers

PMID29535789
PMCPMC5817317
OpenAlexW2784333502

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.