ArticleFrontiers in neuroscience2018
Analysis of Vestibular Labyrinthine Geometry and Variation in the Human Temporal Bone.
Article in Frontiers in neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- IE-Map: a novel in-vivo atlas and template of the human inner ear.Scientific reports · 2021Trial
- A Biophysical Model for Simultaneous Cochlear and Vestibular Nerve Stimulation: Insights into Neural Activation and Crosstalk in Inner Ear Implants.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Machine-driven vs. manual nickel-titanium instrumentation of canine teeth in dogs: a high resolution micro-CT evaluation of canal geometry and obturation quality.Frontiers in veterinary science · 2026Article
- Optimizing spatial normalization of multisubject inner ear MRI: comparison of different geometry-preserving co-registration approaches.Scientific reports · 2025Article
- Modeling of magnetic vestibular stimulation experienced during high-field clinical MRI.Communications medicine · 2025Article
- Optimising electrical vestibular stimulation (EVS) for assessing vestibular function.Clinical neurophysiology practice · 2025Article
- Validation of RNA Extraction Methods and Suitable Reference Genes for Gene Expression Studies in Developing Fetal Human Inner Ear Tissue.International journal of molecular sciences · 2024Article
- Vestibular Extremely Low-Frequency Magnetic and Electric Stimulation Effects on Human Subjective Visual Vertical Perception.Bioelectromagnetics · 2022Article
- Human semicircular canal form: Ontogenetic changes and variation of shape and size.Journal of anatomy · 2022Article
- Article
- Growth and cellular patterning during fetal human inner ear development studied by a correlative imaging approach.BMC developmental biology · 2019Article
- Enhanced contrast in X-ray microtomographic images of the membranous labyrinth using different X-ray sources and scanning modes.Journal of anatomy · 2018Article
- Visualization of the Membranous Labyrinth and Nerve Fiber Pathways in Human and Animal Inner Ears Using MicroCT Imaging.Frontiers in neuroscience · 2018Article
- Model-Based Vestibular Afferent Stimulation: Evaluating Selective Electrode Locations and Stimulation Waveform Shapes.Frontiers in neuroscience · 2018Article
Corrections and comments
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Authors and funding
16 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stable posture and body movement in humans is dictated by the precise functioning of the ampulla organs in the semi-circular canals. Statistical analysis of the interrelationship between bony and membranous compartments within the semi-circular canals is dependent on the visualization of soft tissue structures. Thirty-one human inner ears were prepared, post-fixed with osmium tetroxide and decalcified for soft tissue contrast enhancement. High resolution X-ray microtomography images at 15 μm voxel-size were manually segmented. This data served as templates for centerline generation and cross-sectional area extraction. Our estimates demonstrate the variability of individual specimens from averaged centerlines of both bony and membranous labyrinth. Centerline lengths and cross-sectional areas along these lines were identified from segmented data. Using centerlines weighted by the inverse squares of the cross-sectional areas, plane angles could be quantified. The fit planes indicate that the bony labyrinth resembles a Cartesian coordinate system more closely than the membranous labyrinth. A widening in the membranous labyrinth of the lateral semi-circular canal was observed in some of the specimens. Likewise, the cross-sectional areas in the perilymphatic spaces of the lateral canal differed from the other canals. For the first time we could precisely describe the geometry of the human membranous labyrinth based on a large sample size. Awareness of the variations in the canal geometry of the membranous and bony labyrinth would be a helpful reference in designing electrodes for future vestibular prosthesis and simulating fluid dynamics more precisely.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.