ReviewAdolescent health, medicine and therapeutics2018
Gender dysphoria in adolescence: current perspectives.
Review in Adolescent health, medicine and therapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05010707 (Effectiveness and Safety of Different Estradiol Replacement Therapies in Transgender Female), which is not on this map. Cited by 55 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness and Safety of Different Estradiol Replacement Therapies in Transgender Female
Who cites it
55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 237 citations in OpenAlex.
- Suicide Risk Among Transgender Adolescents and Young Adults: A Meta-Analysis of Nearly One Million Participants.International journal of methods in psychiatric research · 2026Pooled it
- International clinical practice guidelines for gender minority/trans people: systematic review and quality assessment.BMJ open · 2021Pooled it
- Psychosocial and mental health outcomes associated with gender-affirming interventions among transgender youth: a scoping review.Frontiers in public health · 2026Article
- The Cass Review and Gender-Related Care for Young People in Canada: A Commentary on the Canadian Paediatric Society Position Statement on Transgender and Gender-Diverse Youth.Archives of sexual behavior · 2025Article
- Distress Profiles of Adolescents with Gender Dysphoria: A Cluster Analysis Approach.Archives of sexual behavior · 2025Article
- GnRH analogs as a monotherapy in transgender and gender-diverse adolescents: clinical insights from a single-center study.Endocrine connections · 2025Article
- Young Adult and Adolescent Gender-affirming Care: Defining Perioperative Protocols.Plastic and reconstructive surgery. Global open · 2025Article
- An Assessment of the Longitudinal Impact of Gender-affirming Care in an Adolescent and Young Adult Transmasculine and Nonbinary Patient Population.Plastic and reconstructive surgery. Global open · 2025Article
- Autistic Characteristics in a Nationally Representative Clinical Sample of Adolescents Seeking Medical Gender-Affirming Treatment in Norway.Journal of autism and developmental disorders · 2025Article
- The spread of mind: psychological contagion in theory and critique.Frontiers in psychology · 2025Review
- Principlism and contemporary ethical considerations for providers of transgender health care.International journal of transgender health · 2025Article
- Review
- Puberty Suppression for Pediatric Gender Dysphoria and the Child's Right to an Open Future.Archives of sexual behavior · 2024Article
- European Academy of Paediatrics statement on the clinical management of children and adolescents with gender dysphoria.Frontiers in pediatrics · 2024Article
- Assessment of sociodemographic and psychiatric characteristics of transgender adults seen at a Midwest tertiary medical center.Frontiers in endocrinology · 2024Article
- Navigating the landscape: Roles, perspectives, and experiences of psychologists supporting gender diverse children and young people in school settings.International journal of transgender health · 2024Review
- Effectiveness and Safety of Different Estradiol Regimens in Transgender Women (TREAT Study): Protocol for a Randomized Controlled Trial.JMIR research protocols · 2023Article
- Have the psychiatric needs of people seeking gender reassignment changed as their numbers increase? A register study in Finland.European psychiatry : the journal of the Association of European Psychiatrists · 2023Article
- A systematic review on gender dysphoria in adolescents and young adults: focus on suicidal and self-harming ideation and behaviours.Child and adolescent psychiatry and mental health · 2023Review
- Exploring Gender Diversity in Transgender and Non-Binary Adults Accessing a Specialized Service in Italy.Healthcare (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasing numbers of adolescents are seeking treatment at gender identity services in Western countries. An increasingly accepted treatment model that includes puberty suppression with gonadotropin-releasing hormone analogs starting during the early stages of puberty, cross-sex hormonal treatment starting at ~16 years of age and possibly surgical treatments in legal adulthood, is often indicated for adolescents with childhood gender dysphoria (GD) that intensifies during puberty. However, virtually nothing is known regarding adolescent-onset GD, its progression and factors that influence the completion of the developmental tasks of adolescence among young people with GD and/or transgender identity. Consolidation of identity development is a central developmental goal of adolescence, but we still do not know enough about how gender identity and gender variance actually evolve. Treatment-seeking adolescents with GD present with considerable psychiatric comorbidity. There is little research on how GD and/or transgender identity are associated with completion of developmental tasks of adolescence.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.