Evidence map›Paper›PMID 29535546›Full record

ReviewInfection and drug resistance2018

Multidrug-resistant malaria and the impact of mass drug administration.

Janie Anne Zuber, Shannon Takala-Harrison

Abstract readReview
In one paragraph

Review in Infection and drug resistance, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Genetic surveillance for monitoring the impact of drug use on Plasmodium falciparum populations.International journal for parasitology. Drugs and drug resistance · 2021
    Review
  15. Article
  16. Article
  17. Analysis of drug resistance marker genes ofJournal of biosciences · 2021
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Janie Anne ZuberDivision of Malaria Research, Institute for Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Shannon Takala-HarrisonDivision of Malaria Research, Institute for Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.

Funding

Genome-wide studies to identify markers of artemisinin-resistant malariaR01AI101713 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI HARRISON, SHANNON TAKALA · 2013 to 2016
$1.8M
Identification and validation of molecular markers of piperaquine resistanceR01AI125579 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI HARRISON, SHANNON TAKALA · 2017 to 2021
$1.6M
NIAID NIH HHS R01 AI101713NIAID NIH HHS R01 AI125579
6 · The paper itself

Abstract

Based on the emergence and spread throughout the Greater Mekong Subregion (GMS) of multiple artemisinin-resistant lineages, the prevalence of multidrug resistance leading to high rates of artemisinin-based combination treatment failure in parts of the GMS, and the declining malaria burden in the region, the World Health Organization has recommended complete elimination of falciparum malaria from the GMS. Mass drug administration (MDA) is being piloted as one elimination intervention to be employed as part of this effort. However, concerns remain as to whether MDA might exacerbate the already prevalent problem of multidrug resistance in the region. In this review, we briefly discuss challenges of MDA, the use of MDA in the context of multidrug-resistant malaria, and the potential of different drug combinations and drug-based elimination strategies for mitigating the emergence and spread of resistance.

Indexed as

drug resistancemalariamass drug administration

Identifiers

PMID29535546
PMCPMC5840189

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.